Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice

doi:10.1055/a-1659-3908

	Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice
	Bian, Huimiao 1,2; Wang, Yang 3,4; Wu, Peng 1,2; Han, Na 1; Wang, Linlin 2; Li, Xue 2; Zhang, XianJing 2; Cho, Kenka 5; Zhang, Yongyu 3; Yin, Jun 1
刊名	PLANTA MEDICA
	2021-11-05
页码	14
关键词	abdominal aortic aneurysm rosmarinic acid salvianolic acid C salvianolic acid B Salvia miltiorrhiza Bunge Labiatae
ISSN号	0032-0943
DOI	10.1055/a-1659-3908
通讯作者	Yin, Jun(yinjun826@sina.com) ; Jiang, Baohong(jiangbh@simm.ac.cn)
英文摘要	An abdominal aortic aneurysm is a life-threatening cardiovascular disorder caused by dissection and rupture. No effective medicine is currently available for the >90% of patients whose aneurysms are below the surgical threshold. The present study investigated the impact of rosmarinic acid, salvianolic acid C, or salvianolic acid B on experimental abdominal aortic aneurysms. Abdominal aortic aneurysms were induced in apolipoprotein E-deficient mice via infusion of angiotensin II for 4wks. Rosmarinic acid, salvianolic acid C, salvianolic acid B, or doxycycline as a positive control was provided daily through intraperitoneal injection. Administration of rosmarinic acid was found to decrease the thickness of the aortic wall, as determined by histopathological assay. Rosmarinic acid also exhibited protection against elastin fragmentation in aortic media and down-regulated cell apoptosis and proliferation in the aortic adventitia. Infiltration of macrophages, T lymphocytes, and neutrophils in aortic aneurysms was found, especially at the aortic adventitia. Rosmarinic acid, salvianolic acid C, or salvianolic acid B inhibited the infiltration on macrophages specifically, but these compounds did not influence T lymphocytes and neutrophils. Expression of matrix metalloproteinase 9 and macrophage migration inhibitory factor significantly increased in aortic aneurysms. Rosmarinic acid and salvianolic acid C decreased the expression of matrix metalloproteinase-9 in media, and rosmarinic acid also tended to reduce migration inhibitory factor expression. Further then, partial least squares-discriminate analysis was used to classify metabolic changes among different treatments. Rosmarinic acid affected most of the metabolites in the biosynthesis of the citrate cycle, fatty acid pathway significantly. Our present study on mice demonstrated that rosmarinic acid inhibited multiple pathological processes, which were the key features important in abdominal aortic aneurysm formation. Further study on rosmarinic acid, the novel candidate for aneurysmal therapy, should be undertaken to determine its potential for clinical use.
资助项目	National Natural Science Foundation of China[81770478] ; National Natural Science Foundation of China[81770508] ; National Natural Science Foundation of China[81970395] ; Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008] ; Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008-005] ; Shanghai Science and Technology Development Foundation[21S21901900] ; Inter-governmental Science and Technology Innovation Cooperation Program, Ministry of Science and Technology of China[2021YFE0111300]
WOS关键词	SALVIA-MILTIORRHIZA ; ATOPIC-DERMATITIS ; PATHOGENESIS ; INHIBITOR
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000714730000002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298787]
专题	中国科学院上海药物研究所
通讯作者	Yin, Jun; Jiang, Baohong
作者单位	1.Shenyang Pharmaceut Univ, Wenhua Rd 103, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China 3.West Yunnan Univ Appl Sci, Jinghong, Yunnan, Peoples R China 4.Metabo Profile Biotechnol Shanghai Co Ltd, Shanghai, Peoples R China 5.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo, Japan
推荐引用方式 GB/T 7714	Bian, Huimiao,Wang, Yang,Wu, Peng,et al. Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice[J]. PLANTA MEDICA,2021:14.
APA	Bian, Huimiao.,Wang, Yang.,Wu, Peng.,Han, Na.,Wang, Linlin.,...&Jiang, Baohong.(2021).Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice.PLANTA MEDICA,14.
MLA	Bian, Huimiao,et al."Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice".PLANTA MEDICA (2021):14.