Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling

doi:10.1002/jssc.202100542

	Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling
	Guo, Yuejiao 1; Liu, Fang 2,3; Chen, MingCang 2,3; Tian, Qiang 2; Tian, Xiaoting 2,3; Xiong, Qiang 1; Huang, Chenggang 2,3
刊名	JOURNAL OF SEPARATION SCIENCE
	2021-11-05
页码	11
关键词	chronic kidney disease Huangjinsan metabolomics renoprotection traditional Chinese medicine
ISSN号	1615-9306
DOI	10.1002/jssc.202100542
通讯作者	Xiong, Qiang(xiongqiang@njtech.edu.cn) ; Huang, Chenggang(cghsimm@126.com)
英文摘要	Chronic kidney disease is an increasingly serious public health problem worldwide. Our recent studies have shown that Huangjinsan has a renal protective effect on chronic kidney disease, but the specific mechanism by which this effect occurs is not clear. To study the therapeutic effect of Huangjinsan on chronic kidney disease and to explore its possible mechanism of action through nontargeted metabolomics methods, a chronic kidney disease rat model was induced by adenine, and the Huangjinsan extract was given by oral gavage. Body weight, the kidney index, pathological sections, and a series of biochemical indicators were measured. High-performance liquid chromatography quadrupole time-of-flight mass spectrometry was used to analyze the changes in the plasma metabolome. Huangjinsan significantly reduced indicators of kidney damage, including total protein, albumin, the total protein to creatinine ratio, and the albumin to creatinine ratio in urine, as well as IL-2, MCP-1 alpha, and blood urea levels in plasma. Based on nontargeted metabolomics, 13 metabolites related to chronic kidney disease were discovered. These metabolites are closely related to glycerophospholipid metabolism, arginine and proline metabolism, and sphingolipid metabolism. We found that Huangjinsan can restore the renal function of adenine-induced chronic kidney disease by regulating the metabolic profile.
资助项目	Chinese Academy of Science and Technology Service Network Planning[KFJ-STS-QYZD-2021-03-001] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019280] ; National Natural Science Foundation of China for Young Scientists[81803828] ; National Natural Science Foundation of China for Young Scientists[81973456]
WOS关键词	GLOMERULAR-FILTRATION-RATE ; ALL-CAUSE ; LIPIDS ; ALBUMINURIA ; PROLINE ; TISSUE ; APOPTOSIS ; LPC
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000714601000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298778]
专题	中国科学院上海药物研究所
通讯作者	Xiong, Qiang; Huang, Chenggang
作者单位	1.Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 South Puzhu Rd, Nanjing 211816, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Hai Ke Rd Zhangjiang, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yuejiao,Liu, Fang,Chen, MingCang,et al. Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling[J]. JOURNAL OF SEPARATION SCIENCE,2021:11.
APA	Guo, Yuejiao.,Liu, Fang.,Chen, MingCang.,Tian, Qiang.,Tian, Xiaoting.,...&Huang, Chenggang.(2021).Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling.JOURNAL OF SEPARATION SCIENCE,11.
MLA	Guo, Yuejiao,et al."Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling".JOURNAL OF SEPARATION SCIENCE (2021):11.