Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata

doi:10.1021/acs.orglett.1c02772

	Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata
	Zeng, Zi-Rong 1,2,3,4; Li, Wang-Sheng 4; Nay, Bastien 5; Hu, Pei 4; Zhang, Hai-Yan 4; Wang, Hong 1,2,3; Li, Xu-Wen 4; Guo, Yue-Wei 1,2,3,4,6
刊名	ORGANIC LETTERS
	2021-10-01
卷号	23 期号:19 页码:7575-7579
ISSN号	1523-7060
DOI	10.1021/acs.orglett.1c02772
通讯作者	Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Wang, Hong(hongw@zjut.edu.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	A novel diterpenoid, sinunanolobatone A (1), featuring an unprecedented bicyclo[13.1.0]pentadecane carbon framework, along with two new casbane diterpenoids (2 and 3), and five known related ones (4-8) were isolated from the Sanya soft coral Sinularia nanolobata. The structures of the new compounds were established by detailed spectroscopic analysis, X-ray diffraction analysis, chemical reactions, or a quantum chemical computation method. A plausible biosynthetic pathway of 1 was proposed. In bioassay, the novel compound 1 showed significant inhibitory activity against lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells.
资助项目	National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS关键词	TERPENOIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000704710800050
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298457]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Hai-Yan; Wang, Hong; Li, Xu-Wen; Guo, Yue-Wei
作者单位	1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China 2.Zhejiang Univ Technol, Coll Pharmaceut, Hangzhou 310014, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Ecole Polytech, Lab Synth Organ, F-91128 Palaiseau, France 6.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Zi-Rong,Li, Wang-Sheng,Nay, Bastien,et al. Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata[J]. ORGANIC LETTERS,2021,23(19):7575-7579.
APA	Zeng, Zi-Rong.,Li, Wang-Sheng.,Nay, Bastien.,Hu, Pei.,Zhang, Hai-Yan.,...&Guo, Yue-Wei.(2021).Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata.ORGANIC LETTERS,23(19),7575-7579.
MLA	Zeng, Zi-Rong,et al."Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata".ORGANIC LETTERS 23.19(2021):7575-7579.