Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

doi:10.1016/j.jmst.2021.03.074

CORC > 金属研究所 > 中国科学院金属研究所

	Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys
	Ren, Ling 1; Xu, Xiaohe 2; Liu, Hui 1,3; Yang, Ke 1; Qi, Xun 4
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2021-12-30
卷号	95 页码:237-248
关键词	Cu ions Kinetic Biocompatibility Titanium
ISSN号	1005-0302
DOI	10.1016/j.jmst.2021.03.074
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com)
英文摘要	To reduce the risk of implant-associated infections, we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role. However, both excessive and deficient Cu levels adversely affect human health; therefore, the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo . Moreover, the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated. The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate. The release rate maintained at a parts per billion level safe for humans; consequently, we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals.
资助项目	National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC110060 0] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; National Natural Science Foundation[81873918] ; Startup Fundation for Docotors of Liaoning Province[2019BS-293]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000733964500002
资助机构	National Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Startup Fundation for Docotors of Liaoning Province
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/167246]
专题	金属研究所_中国科学院金属研究所
通讯作者	Yang, Ke; Qi, Xun
作者单位	1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Ren, Ling,Xu, Xiaohe,Liu, Hui,et al. Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,95:237-248.
APA	Ren, Ling,Xu, Xiaohe,Liu, Hui,Yang, Ke,&Qi, Xun.(2021).Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,95,237-248.
MLA	Ren, Ling,et al."Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 95(2021):237-248.