Impaired delay discounting and time sensitivity in methcathinone use disorder
Zeng, Ningning4,5; Zheng, Hui4; Shi, Tianshu6; Zhang, Hang-Bin4; Wang, Li-Xun7; Liang, Zhu-Yuan1,8; Sun, Bomin3; Liao, Yanhui2; Rao, Li-Lin1,8; Yang, Bo6
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
2022-01-29
通讯作者邮箱raoll@psych.ac.cn (li-lin rao ) ; zsdybo@sina.com (bo yang ) ; ytf0707@126.com (ti-fei yuan )
页码8
关键词Intertemporal decision-making Constant sensitivity modeling Methcathinone Addiction
ISSN号0940-1334
DOI10.1007/s00406-021-01372-7
产权排序5
文献子类实证研究
英文摘要

Substance use disorder (SUD) is characterized by continued drug use despite adverse consequences. Methcathinone is a new type of psychoactive substance that is associated with high excitement and impulsive behaviors. However, it is unclear if individuals with methcathinone use disorders (MCUD) are with impaired decision-making ability. We analyzed the task performance in 45 male MCUD subjects and 35 male matched healthy controls (HC) with intertemporal decision-making task. Constant sensitivity discounting model was used to estimate potential changes in both discounting rate and time sensitivity. The results showed that MCUD individuals exhibited a higher delay discounting rate (p = 0.003, Cohen's d = 0.683) and reduced sensitivity to time (p < 0.001, Cohen's d = 1.662). The delay discounting rate was correlated to the first age for drug use (r = - 0.41, p = 0.004), and the time sensitivity was negatively correlated with the duration of abstinence (r = - 0.31, p = 0.036). We conclude that MCUD individuals are with impaired decision-making ability and time perception disturbances.

收录类别SCI
资助项目Guangdong grant 'Key technologies for the treatment of brain disorders'[2018B030331001] ; Hundred-Talent Fund from Shanghai Municipal Commission of Health[2018BR21] ; Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University[ZH2018ZDA30] ; innovative research team of high-level local universities in Shanghai
WOS关键词DECISION-MAKING ; IMPULSIVITY ; DRUG ; SEVERITY ; REWARD ; CHOICE ; KHAT
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:000749053800001
资助机构Guangdong grant 'Key technologies for the treatment of brain disorders' ; Hundred-Talent Fund from Shanghai Municipal Commission of Health ; Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University ; innovative research team of high-level local universities in Shanghai
内容类型期刊论文
源URL[http://ir.psych.ac.cn/handle/311026/41902]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Rao, Li-Lin; Yang, Bo; Yuan, Ti-Fei
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
2.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Peoples R China
3.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Funct Neurosurg, Sch Med, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China
5.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Shenzhen, Peoples R China
6.China Univ Polit Sci & Law, Sch Sociol, Beijing, Peoples R China
7.Changzhi Drug Rehabil Ctr, Changzhi, Peoples R China
8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
9.Tongji Univ, Translat Res Inst Brain & Brain Intelligence, Sch Med, Shanghai Peoples Hosp 4, Shanghai, Peoples R China
10.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Ningning,Zheng, Hui,Shi, Tianshu,et al. Impaired delay discounting and time sensitivity in methcathinone use disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2022:8.
APA Zeng, Ningning.,Zheng, Hui.,Shi, Tianshu.,Zhang, Hang-Bin.,Wang, Li-Xun.,...&Yuan, Ti-Fei.(2022).Impaired delay discounting and time sensitivity in methcathinone use disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,8.
MLA Zeng, Ningning,et al."Impaired delay discounting and time sensitivity in methcathinone use disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022):8.
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