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题名	脊髓静息态功能网络的可重复性研究
作者	田广悦
答辩日期	2021-12
文献子类	硕士
授予单位	中国科学院心理研究所
授予地点	中国科学院心理研究所
其他责任者	孔亚卓
关键词	脊髓磁共振成像 静息态功能网络 可重复性
学位名称	理学硕士
其他题名	Test-retest reliability of resting state functional network of spinal cord
学位专业	认知神经科学
中文摘要	In recent years, spinal cord magnetic resonance imaging technology has developed rapidly. Due to the important physiological function of the spinal cord, resting functional magnetic resonance imaging technology of the spinal cord has great application prospects in basic research and clinic. However, compared with the brain, the spinal cord's physiological structure and surrounding tissue environment are more complex, so the imaging is more vulnerable to physiological noise, which poses a great challenge to the test-retest reliability of the experimental results. Verifying the test-retest reliability of the spinal cord resting一state functional network is very important to the credibility of basic research results. It is also a prerequisite for the application of spinal cord magnetic resonance imaging technology in the clinic. There have been many studies on test-retest reliability in the brain network. However, at present, there is no research on the test-retest reliability of magnetic resonance structural images of the spinal cord. There are few studies on the test-retest reliability of the resting functional network of the spinal cord. Some problems include the small number of subjects (about 10), short scanning interval (within 1h), and limited analysis methods. Because of this situation, this study collected the spinal cord structure and functional image data through two scans at an interval of two weeks to further study the test-retest reliability of spinal cord structure imaging and spinal cord resting functional network. In this study, through two scans of magnetic resonance structural images of the spinal cord, taking the cross一sectional area as the structural characteristics of the spinal cord, it is proved that the results of magnetic resonance structural imaging of the spinal cord have good test-retest reliability, which is similar to the results obtained by predecessors in the brain. In this study, two methods based on seed point and frequency domain analysis were used to process the pretreated spinal cord resting functional image data, and then to study the test-retest reliability of subjects scanning spinal cord resting functional network every two weeks. Using the seed point-based method, we found that the functional connections within the dorsal and ventral angles were generally repeatable, and the functional connections between the dorsal and ventral angles were generally repeatable. Using the method of frequency domain analysis, we take ALFF and fALFF as indicators and find that ALFF and fALFF indicators show a general degree of test-retest reliability. By comparing the data before and after preprocessing, it is found that whether using the method based on seed point or frequency domain analysis, the test-retest reliability results obtained from the data analysis after preprocessing are significantly greater than those before preprocessing, which proves that the preprocessing process adopted in this experiment effectively reduces the noise and improves the test-retest reliability of the resting functional network of the spinal cord. To sum up, this experiment proves that, similar to the brain structure, the structural image of the spinal cord has good test-retest reliability; After proper pretreatment, the test-retest reliability of the resting functional network of the spinal cord can also approach or reach the level of the brain network.
英文摘要	近年来，脊髓磁共振成像技术迅速发展，由于脊髓重要的生理功能，脊髓的静息态功能磁共振成像技术在基础研究和临床方面都有着巨大的应用前景。然而，相比于大脑而言，脊髓的生理结构和周围组织环境更为复杂，因此成像更易受到生理噪声的影响，这对实验结果的可重复性提出了巨大挑战。验证脊髓静息态功能网络可重复性对基础研究结果的可信度至关重要，同时也是脊髓磁共振成像技术应用于临床的先决条件。可重复性问题在脑网络中已有较多研究，然而，目前尚没有关于脊髓磁共振结构像可重复性的研究，关于脊髓静息态功能网络的可重复性的研究也很少，并且存在被试数量较少(10个左右)，扫描间隔时间较短Clh以内)，且使用的分析方法较为局限等问题。针对这一现状，本研究通过间隔两周的两次扫描，采集被试的脊髓结构和功能像数据，从而对脊髓结构成像和脊髓静息态功能网络的可重复性作进一步研究。 本研究通过两次脊髓磁共振结构像的扫描，以横截面积作为脊髓结构特征，证明了脊髓的磁共振结构成像结果具有很好的可重复性，这点和前人在大脑中取得的结果是类似的。 本研究选择采用基于种子点和频域分析两种方法来处理预处理之后的脊髓静息态功能像数据，进而研究被试相隔两周扫描脊髓静息态功能网络的可重复性。应用基于种子点的方法，我们发现，背角和腹角内部的功能连接总体表现为中等程度的可重复性，背角和腹角之间的功能连接总体表现为一般程度的可重复性。使用频域分析的方法，我们以ALFF和fALFF作为指标，发现ALFF和fALFF指标均表现出一般程度的可重复性。 本研究通过对比预处理前后的数据，发现无论使用基于种子点还是频域分析的方法，预处理后的数据分析得到的可重复性结果都显著大于预处理前，这证明了本实验所采取的预处理流程有效地较少了噪声，从而提高了脊髓静息态功能网络的可重复性。 综上，本实验证明了，和大脑结构类似，脊髓的结构功能像具有很好的可重复性;经过适当的预处理流程，脊髓的静息态功能网络的可重复性也能接近或达到脑网络的水平。
语种	中文
内容类型	学位论文
源URL	[http://ir.psych.ac.cn/handle/311026/41344]
专题	心理研究所_认知与发展心理学研究室
推荐引用方式 GB/T 7714	田广悦. 脊髓静息态功能网络的可重复性研究[D]. 中国科学院心理研究所. 中国科学院心理研究所. 2021.

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