Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: A systematic review

doi:10.1002/cam4.3134

	Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: A systematic review
	Li, Chengcheng 2; Zhang, Qiuning 1,3; Li, Zheng 1; Feng, Shuangwu 2; Luo, Hongtao 1; Liu, Ruifeng 1; Wang, Lina 2; Geng, Yichao 2; Zhao, Xueshan 2; Yang, Zhen 4
刊名	CANCER MEDICINE
	2020-06-10
页码	13
关键词	carbon-ion radiotherapy malignant melanoma systematic review
ISSN号	2045-7634
DOI	10.1002/cam4.3134
通讯作者	Wang, Xiaohu(xhwanggansu@163.com)
英文摘要	Malignant melanomas (MMs) were the fifth most common cancer in men and the sixth most common cancer in women in 2018, respectively. These are characterized by high metastatic rates and poor prognoses. We systematically reviewed safety and efficacy of carbon-ion radiotherapy (CIRT) for treating MMs. Eleven studies were eligible for review, and the data showed that MM patients showed better local control with low recurrence and mild toxicities after CIRT. Survival rates were slightly higher in patients with cutaneous or uveal MMs than in those with mucosal MMs. CIRT in combination with chemotherapy produced higher progression-free survival rates than CIRT only. In younger patients, higher rates of distant metastases of gynecological MMs were observed. The data indicated that CIRT is effective and safe for treating MMs; however, a combination with systemic therapy is recommended to ensure the best possible prognosis for MMs.
资助项目	Lanzhou Innovation and Entrepreneurship Talent Project[2017-RC-23]
WOS关键词	LOCATED CHOROIDAL MELANOMA ; MUCOSAL MELANOMA ; RADIATION-THERAPY ; SINGLE-ARM ; OPEN-LABEL ; HIGH-RISK ; PHASE-II ; HEAD ; NECK ; IPILIMUMAB
WOS研究方向	Oncology
语种	英语
出版者	WILEY
WOS记录号	WOS:000539184400001
资助机构	Lanzhou Innovation and Entrepreneurship Talent Project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/140390]
专题	中国科学院近代物理研究所
通讯作者	Wang, Xiaohu
作者单位	1.Chinese Acad Sci, Inst Modern Phys, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China 2.Lanzhou Univ, Sch Clin Med 1, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China 3.Lanzhou Heavy Ions Hosp, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China 4.Lanzhou Univ, Basic Med Coll, Lanzhou, Peoples R China 5.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Chengcheng,Zhang, Qiuning,Li, Zheng,et al. Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: A systematic review[J]. CANCER MEDICINE,2020:13.
APA	Li, Chengcheng.,Zhang, Qiuning.,Li, Zheng.,Feng, Shuangwu.,Luo, Hongtao.,...&Wang, Xiaohu.(2020).Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: A systematic review.CANCER MEDICINE,13.
MLA	Li, Chengcheng,et al."Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: A systematic review".CANCER MEDICINE (2020):13.