Biomarkers of Brain Damage Induced by Radiotherapy

doi:10.1177/1559325820938279

	Biomarkers of Brain Damage Induced by Radiotherapy
	Sultana, Nahida 1; Sun, Chao 2; Katsube, Takanori 3; Wang, Bing 3
刊名	DOSE-RESPONSE
	2020-07-01
卷号	18 期号:3 页码:10
关键词	biomarker cranial radiotherapy radiation-induced brain damage cognitive impairment
ISSN号	1559-3258
DOI	10.1177/1559325820938279
通讯作者	Sultana, Nahida(kochi.haque2012@gmail.com) ; Wang, Bing(wang.bing@qst.go.jp)
英文摘要	Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered as a critical clinical disadvantage especially for the whole brain radiotherapy. Biomarkers can help to detect the accurate physiology or conditions of patients with brain tumor and develop effective treatment procedures for these patients. In the near future, biomarkers will become one of the prime driving forces of cancer treatment. In this minireview, we analyze the documented work on the acute brain damage and late consequences induced by radiotherapy, identify the biomarkers, in particular, the predictive biomarkers for the damage, and summarize the biological significance of the biomarkers. It is expected that translation of these research advance to radiotherapy would assist stratifying patients for optimized treatment and improving therapeutic efficacy and the quality of life.
资助项目	Ministry of Education, Culture, Sport, Sciences and Technology (MEXT)[15H05935] ; MEXT, Japan ; Nuclear Safety Research Association, Japan
WOS关键词	CENTRAL-NERVOUS-SYSTEM ; ENDOTHELIAL GROWTH-FACTOR ; APPEARING WHITE-MATTER ; MAGNETIC-RESONANCE-SPECTROSCOPY ; RADIATION-INDUCED CHANGES ; DIFFUSION TENSOR ; NORMAL TISSUE ; CRANIAL IRRADIATION ; STEREOTACTIC RADIOSURGERY ; PROGNOSTIC-SIGNIFICANCE
WOS研究方向	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000551666400001
资助机构	Ministry of Education, Culture, Sport, Sciences and Technology (MEXT) ; MEXT, Japan ; Nuclear Safety Research Association, Japan
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/140228]
专题	中国科学院近代物理研究所
通讯作者	Sultana, Nahida; Wang, Bing
作者单位	1.Bangladesh Atom Energy Commiss, Atom Energy Res Estab, Inst Food & Radiat Biol, Dhaka 1207, Bangladesh 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 3.Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Chiba 2638555, Japan
推荐引用方式 GB/T 7714	Sultana, Nahida,Sun, Chao,Katsube, Takanori,et al. Biomarkers of Brain Damage Induced by Radiotherapy[J]. DOSE-RESPONSE,2020,18(3):10.
APA	Sultana, Nahida,Sun, Chao,Katsube, Takanori,&Wang, Bing.(2020).Biomarkers of Brain Damage Induced by Radiotherapy.DOSE-RESPONSE,18(3),10.
MLA	Sultana, Nahida,et al."Biomarkers of Brain Damage Induced by Radiotherapy".DOSE-RESPONSE 18.3(2020):10.