High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis

doi:10.3389/fonc.2021.650488

	High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis
	Hu, Xiaoli 2,3,4,5,6; Liu, Yang 2,3,4,5,6; Bing, Zhitong 2; Ye, Qian 3,4,6,7; Li, Chengcheng 1
刊名	FRONTIERS IN ONCOLOGY
	2021-11-26
卷号	11 页码:10
关键词	MSN lymph node metastasis prognosis breast cancer meta-analysis
ISSN号	2234-943X
DOI	10.3389/fonc.2021.650488
通讯作者	Liu, Yang(liuy@impcas.ac.cn)
英文摘要	Owing to metastases and drug resistance, the prognosis of breast cancer is still dismal. Therefore, it is necessary to find new prognostic markers to improve the efficacy of breast cancer treatment. Literature shows a controversy between moesin (MSN) expression and prognosis in breast cancer. Here, we aimed to conduct a systematic review and meta-analysis to evaluate the prognostic relationship between MSN and breast cancer. Literature retrieval was conducted in the following databases: PubMed, Web of Science, Embase, and Cochrane. Two reviewers independently performed the screening of studies and data extraction. The Gene Expression Omnibus (GEO) database including both breast cancer gene expression and follow-up datasets was selected to verify literature results. The R software was employed for the meta-analysis. A total of 9 articles with 3,039 patients and 16 datasets with 2,916 patients were ultimately included. Results indicated that there was a significant relationship between MSN and lymph node metastases (P < 0.05), and high MSN expression was associated with poor outcome of breast cancer patients (HR = 1.99; 95% CI 1.73-2.24). In summary, there is available evidence to support that high MSN expression has valuable importance for the poor prognosis in breast cancer patients.
资助项目	National Natural Science Foundation of China[11575262]
WOS关键词	INVADOPODIA FORMATION ; ERM PROTEINS ; MATRIX-METALLOPROTEINASE ; CORTACTIN ; MARKER ; EZRIN ; CELLS ; EZRIN/RADIXIN/MOESIN ; METASTASIS ; FAMILY
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000731901300001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/140117]
专题	中国科学院近代物理研究所
通讯作者	Liu, Yang
作者单位	1.Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China 2.Adv Energy Sci & Technol Guangdong Lab, Huizhou, Peoples R China 3.Key Lab Heavy Radiat Med Gansu Prov, Lanzhou, Peoples R China 4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou, Peoples R China 5.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou, Peoples R China 7.Lanzhou Univ, Sch Stomatol, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiaoli,Liu, Yang,Bing, Zhitong,et al. High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis[J]. FRONTIERS IN ONCOLOGY,2021,11:10.
APA	Hu, Xiaoli,Liu, Yang,Bing, Zhitong,Ye, Qian,&Li, Chengcheng.(2021).High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis.FRONTIERS IN ONCOLOGY,11,10.
MLA	Hu, Xiaoli,et al."High Moesin Expression Is a Predictor of Poor Prognosis of Breast Cancer: Evidence From a Systematic Review With Meta-Analysis".FRONTIERS IN ONCOLOGY 11(2021):10.