Role of miR-302/367 cluster in human physiology and pathophysiology

doi:10.1093/abbs/gmaa065

	Role of miR-302/367 cluster in human physiology and pathophysiology
	Guo, Menghuan 1; Gan, Lu 4,5,6; Si, Jing 4,5,6; Zhang, Jinhua 4,5,6; Liu, Zhiyuan 3; Zhao, Jin 2; Gou, Zhong 2; Zhang, Hong 1,4,5,6
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2020-08-01
卷号	52 期号:8 页码:791-800
关键词	miR-302/367 cluster pluripotent stem cells cancer central nervous system cardiovascular system
ISSN号	1672-9145
DOI	10.1093/abbs/gmaa065
通讯作者	Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target mRNAs at the post-transcriptional level. Increasing evidence shows the involvement of miRNAs in diverse biological processes. miR-302/367 cluster is highly conserved among vertebrates and made up of five members, including miR-367, miR-302a, miR-302b, miR-302c and miR-302d. miR-302/367 cluster plays an important role in cell proliferation, differentiation and reprogramming, affecting the development of tumor, cardiovascular system, nervous system and immune system. In this review, we will summarize the role of miR-302/367 cluster in embryonic stem cells and induced pluripotent stem cells and try to point out its relationship with tumors, cardiovascular system, nervous system and immune system.
资助项目	Ministry of Science and Technology National Key RD Project[2018YFE0205100] ; National Natural Science Foundation of China[31560254] ; National Natural Science Foundation of China[81960337] ; National Natural Science Foundation of China[81560508] ; National Natural Science Foundation of China[11775289] ; Fundamental Research Funds for the Central Universities[31920160048]
WOS关键词	MIR-367 PROMOTES PROLIFERATION ; EMBRYONIC STEM-CELLS ; HEPATOCELLULAR-CARCINOMA ; CARDIOMYOCYTE PROLIFERATION ; UNFAVORABLE PROGNOSIS ; CYCLIN D1 ; MICRORNA ; EXPRESSION ; SUPPRESSES ; INVASION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000574289000001
资助机构	Ministry of Science and Technology National Key RD Project ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139687]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Hong
作者单位	1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China 2.Northwest Minzu Univ, Med Coll, Lanzhou 730030, Peoples R China 3.Northwest Minzu Univ, Sch Chem Engn, Lanzhou 730030, Peoples R China 4.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 6.Chinese Acad Sci, Biomed Res Ctr, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Guo, Menghuan,Gan, Lu,Si, Jing,et al. Role of miR-302/367 cluster in human physiology and pathophysiology[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2020,52(8):791-800.
APA	Guo, Menghuan.,Gan, Lu.,Si, Jing.,Zhang, Jinhua.,Liu, Zhiyuan.,...&Zhang, Hong.(2020).Role of miR-302/367 cluster in human physiology and pathophysiology.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,52(8),791-800.
MLA	Guo, Menghuan,et al."Role of miR-302/367 cluster in human physiology and pathophysiology".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 52.8(2020):791-800.