Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

doi:10.3390/ijms21228879

	Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases
	Huang, Guomin 1,2,3,4,5; Li, Hongyan 1,2,3,4,5; Zhang, Hong 1,2,3,4,5
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2020-11-01
卷号	21 期号:22 页码:19
关键词	mitochondrial ribosome mitochondrial ribosomal proteins apoptosis cancer mitochondrial disease biomarker
DOI	10.3390/ijms21228879
通讯作者	Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors. This paper reviews the basic structure of mitochondrial ribosome, focuses on the structure and function of MRPs, and their relationships with cell apoptosis and diseases. It provides a reference for the study of the function of MRPs and the disease diagnosis and treatment.
资助项目	National Key R&D Program of China[2018YFE0205100] ; National Natural Science Foundation of China[11875061] ; National Natural Science Foundation of China[11505244] ; National Natural Science Foundation of Gansu province[20JR5RA550] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Laboratory of Heavy ion Accelerator of Lanzhou[E0HIRFL03P]
WOS关键词	DEATH-ASSOCIATED PROTEIN-3 ; BREAST-CANCER ; CRYSTAL-STRUCTURE ; WIDE ASSOCIATION ; CANDIDATE GENES ; FUNCTIONAL-ROLE ; SMALL-SUBUNIT ; MUTATION ; DELETION ; CRIF1
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000594925300001
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of Gansu province ; Key Program of the National Natural Science Foundation of China ; National Laboratory of Heavy ion Accelerator of Lanzhou
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139346]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Hong
作者单位	1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China 2.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing 101408, Peoples R China 5.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Huang, Guomin,Li, Hongyan,Zhang, Hong. Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(22):19.
APA	Huang, Guomin,Li, Hongyan,&Zhang, Hong.(2020).Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(22),19.
MLA	Huang, Guomin,et al."Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.22(2020):19.