Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system

doi:10.1371/journal.pone.0238209

	Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system
	Zhao, Baoquan 2; Li, Xiaoman 1,2,3; Li, Xingzhou 2; Quan, Dongqin 2; Zhang, Fang 2; Hu, Burong 3
刊名	PLOS ONE
	2021-01-29
卷号	16 期号:1 页码:15
ISSN号	1932-6203
DOI	10.1371/journal.pone.0238209
通讯作者	Zhao, Baoquan(baoquanzhao@126.com)
英文摘要	Ilomastat, a broad-spectrum inhibitor of matrix metalloproteinases (MMPs), has drawn attentions for its function in alleviating radiation damage. However, the detailed mechanisms of Ilomastat's protection from animal model remain not fully clear. In this study, the C57BL/6 mice were pre-administrated with Ilomastat or vihicle for 2 h, and then total body of mice were exposed to 6 Gy of gamma-rays. The protective effect of Ilomastat on the hematopoietic system in the irradiated mice were investigated. We found that pretreatment with Ilomastat significantly reduced the level of TGF-beta 1 and TNF-alpha, and elevated the number of bone marrow (BM) mononuclear cells in the irradiated mice. Ilomastat pretreatment also increased the fraction of BM hematopoietic progenitor cells (HPCs) and hematopoietic stem cells (HSCs) at day 30 after irradiation, and protected the spleen of mouse from irradiation. These results suggest that Ilomastat promotes the recovery of hematopoietic injury in the irradiated mice, and thus contributes to the survival of mouse after irradiation.
资助项目	Military Medical Scientific and Technological Project[AWS17J009] ; Military Medical Scientific and Technological Project[BWS16J007] ; Military Medical Scientific and Technological Project[2018ZX09J18102] ; National Natural Science Foundation of China[11635013]
WOS关键词	NECROSIS-FACTOR-ALPHA ; BONE-MARROW ; MATRIX METALLOPROTEINASES ; RADIATION ; STEM ; INJURY ; MICE ; APOPTOSIS ; CELLS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000613891400029
资助机构	Military Medical Scientific and Technological Project ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137754]
专题	中国科学院近代物理研究所
通讯作者	Zhao, Baoquan
作者单位	1.Peking Univ, Sch Basic Med Sci, Inst Syst Biomed, Dept Radiat Med,Hlth Sci Ctr, Beijing, Peoples R China 2.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Baoquan,Li, Xiaoman,Li, Xingzhou,et al. Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system[J]. PLOS ONE,2021,16(1):15.
APA	Zhao, Baoquan,Li, Xiaoman,Li, Xingzhou,Quan, Dongqin,Zhang, Fang,&Hu, Burong.(2021).Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system.PLOS ONE,16(1),15.
MLA	Zhao, Baoquan,et al."Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system".PLOS ONE 16.1(2021):15.