Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment

doi:10.1016/j.ejmp.2021.06.005

	Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment
	He, Pengbo 1,2,3,4; Li, Qiang 1,2,3,4
刊名	PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
	2021-07-01
卷号	87 页码:99-105
关键词	Carbon ion therapy 4D dose calculation Respiratory guidance Synchrotron magnetic excitation pattern
ISSN号	1120-1797
DOI	10.1016/j.ejmp.2021.06.005
通讯作者	Li, Qiang(liqiang@impcas.ac.cn)
英文摘要	Purpose: A novel variable cycle-based respiratory guidance method was proposed to synchronize the patterns between patients' breathing and the magnetic excitation of synchrotron under the mode of full-energy depth scanning beam delivery, in order to improve the treatment precision and efficiency for carbon ion therapy. Methods: Audio-visual biofeedback system with variable cycle-based respiratory guidance method was developed. We enrolled 6 healthy volunteers and a simulation study of the fixed cycle-based and variable cycle-based respiratory guidance with three treatment fractions was performed. A total of 72 breathing curves were collected for 4D dose calculations with three 4DCT datasets of lung tumor cases. Target dose coverage (D95: the percent dose covering 95% of the target), dose homogeneity (D5-D95), and treatment time were analyzed. The Wilcoxon signed-rank test was used for statistical difference analysis, and p < 0.05 was considered significant. Results: With the variable cycle-based respiratory guidance method, the breath hold phase of breathing curve could be synchronized with the synchrotron flat-top phase over time. The dose homogeneity was improved by factors of 1.94-2.92 compared to the fixed cycle-based respiratory guidance maneuvers alone or in combination with gating technique. Moreover, the treatment efficiency increased by 11-23%, depending on the duty cycle settings of the gating window. Conclusions: The proposed variable cycle-based respiratory guidance method could improve both the treatment efficiency and precision under the mode of the full-energy depth scanning beam delivery for synchrotron-based carbon ion therapy.
资助项目	National Natural Science Foundation of China[11705247] ; National Natural Science Foundation of China[11875299] ; Youth Innovation Promotion Association, Chinese Academy of Sciences, China[2019405] ; National Key Research and Development Program of China[2018YFC0115702]
WOS关键词	GATED DELIVERY ; RADIOTHERAPY ; OPTIMIZATION ; IRRADIATION ; LIVER
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000669669100011
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences, China ; National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137062]
专题	中国科学院近代物理研究所
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	He, Pengbo,Li, Qiang. Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment[J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,2021,87:99-105.
APA	He, Pengbo,&Li, Qiang.(2021).Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment.PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,87,99-105.
MLA	He, Pengbo,et al."Motion management with variable cycle-based respiratory guidance method for carbon-ion pencil beam scanning treatment".PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 87(2021):99-105.