LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation | |
Kuang, Yanbei1,2,3,4; Bing, Zhitong1,2,3,4; Jin, Xiaodong1,2,3,4; Li, Qiang1,2,3,4 | |
刊名 | BIOMED RESEARCH INTERNATIONAL |
2021-06-01 | |
卷号 | 2021页码:10 |
ISSN号 | 2314-6133 |
DOI | 10.1155/2021/1728352 |
通讯作者 | Jin, Xiaodong(jinxd@impcas.ac.cn) ; Li, Qiang(liqiang@impcas.ac.cn) |
英文摘要 | Previous studies have indicated that radiation resistance of glioma is one of the leading causes of radiotherapy failure. Mounting evidence suggests that long non-coding RNA (lncRNA) plays an important role in regulating radiosensitivity of cancer cells via implicating in various cell processes. However, the underlying mechanisms remain unclear and need further study, especially at the molecular level. We found that the expression level of lncRNA H19 was elevated by radiation, and then, the modulation of H19 affected the resistant of glioma cells to X-rays. Dual-luciferase reporter analyses showed that H19 was transcriptionally activated by CREB1 in glioma cells after irradiation. In addition, both flow cytometry and 5-ethynyl-2'-deoxyuridine (EdU) assay suggested that H19 was involved in the cell cycle arrest, apoptosis, and DNA synthesis to modulate the radiation response of glioma cells and influenced their radioresistance. Therefore, H19 might play a crucial role in enhancing the radioresistance of glioma. |
资助项目 | National Key Research Program of China[2018YFC0115700] ; National Key Research Program of China[2018YFC0115702] ; National Natural Science Foundation of China[11875299] ; National Natural Science Foundation of China[U1532264] ; Key Deployment Project of Chinese Academy of Sciences[KFZD-SW-222] ; National Natural Science Foundation of Chinese Academy of Engineering Physics[U1730133] |
WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; CREB ; PROLIFERATION ; TUMORS |
WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
语种 | 英语 |
出版者 | HINDAWI LTD |
WOS记录号 | WOS:000664104000006 |
资助机构 | National Key Research Program of China ; National Natural Science Foundation of China ; Key Deployment Project of Chinese Academy of Sciences ; National Natural Science Foundation of Chinese Academy of Engineering Physics |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.186/handle/113462/137032] |
专题 | 中国科学院近代物理研究所 |
通讯作者 | Jin, Xiaodong; Li, Qiang |
作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Kuang, Yanbei,Bing, Zhitong,Jin, Xiaodong,et al. LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:10. |
APA | Kuang, Yanbei,Bing, Zhitong,Jin, Xiaodong,&Li, Qiang.(2021).LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation.BIOMED RESEARCH INTERNATIONAL,2021,10. |
MLA | Kuang, Yanbei,et al."LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation".BIOMED RESEARCH INTERNATIONAL 2021(2021):10. |
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