Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer

doi:10.1177/15593258211033114

	Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer
	Xu, Shuai 4,5; Huang, Hefa 6; Tang, Deping 3; Xing, Mengjie 3; Zhao, Qiuyue 1,5; Li, Jianping 4; Si, Jing 5; Gan, Lu 5; Mao, Aihong 2,5; Zhang, Hong 5
刊名	DOSE-RESPONSE
	2021-07-01
卷号	19 期号:3 页码:11
关键词	diallyl disulfide ionizing radiation migration invasion Nrf2 non-small-cell lung cancer
ISSN号	1559-3258
DOI	10.1177/15593258211033114
通讯作者	Mao, Aihong(maoaih@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths. Radiotherapy remains the primary treatment method for NSCLC. Despite great advances in radiotherapy techniques and modalities, recurrence and resistance still limit therapeutic success, even low-dose ionizing radiation (IR) can induce the migration and invasion. Diallyl disulfide (DADS), a bioactive component extracted from garlic, exhibits a wide spectrum of biological activities including antitumor effects. However, the effect of DADS on IR-induced migration and invasion remains unclear. The present study reported that IR significantly promoted the migration and invasion of A549 cells. Pretreatment with 40 mu M DADS enhanced the radiosensitivity of A549 cells and attenuated IR-induced migration and invasion. In addition, 40 mu M DADS inhibited migration-related protein matrix metalloproteinase-2 and 9 (MMP-2/9) expression and suppressed IR-aggravated EMT by the upregulation of the epithelial marker, E-cadherin, and downregulation of the mesenchymal marker, N-cadherin, in A549 cells. Furthermore, DADS was found to inhibit the activation of Nrf2 signaling. Based on our previous results that knockdown of Nrf2 by siRNA suppressed IR-induced migration and invasion in A549 cells, we speculated that DADS attenuated IR-induced migration and invasion by suppressing the activation of Nrf2 signaling in A549 cells.
资助项目	Ministry of Science and Technology National Key RD project[2018YFE020524] ; National Natural Science Foundation of China[12065001] ; Gansu Provincial Science and Technology Project[20YF3FA021] ; Innovation Fund of Colleges and Universities in Gansu Province[2020A-041] ; Zhaoqing Science and Technology Innovation Guidance Project[201904031412]
WOS关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; DOWN-REGULATION ; METASTASIS ; RADIOTHERAPY ; MUTATIONS ; ADENOCARCINOMA ; INHIBITION ; ACTIVATION ; EXPRESSION ; PATHWAY
WOS研究方向	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000691402200001
资助机构	Ministry of Science and Technology National Key RD project ; National Natural Science Foundation of China ; Gansu Provincial Science and Technology Project ; Innovation Fund of Colleges and Universities in Gansu Province ; Zhaoqing Science and Technology Innovation Guidance Project
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136399]
专题	中国科学院近代物理研究所
通讯作者	Mao, Aihong; Zhang, Hong
作者单位	1.Sichuan Univ, Human Resources Off, Chengdu, Peoples R China 2.Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China 3.Lanzhou Jiaotong Univ, Sch Biol & Pharmaceut Engn, Lanzhou, Peoples R China 4.Zhaoqing Med Coll, Zhaoqing, Peoples R China 5.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 6.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Xu, Shuai,Huang, Hefa,Tang, Deping,et al. Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer[J]. DOSE-RESPONSE,2021,19(3):11.
APA	Xu, Shuai.,Huang, Hefa.,Tang, Deping.,Xing, Mengjie.,Zhao, Qiuyue.,...&Zhang, Hong.(2021).Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer.DOSE-RESPONSE,19(3),11.
MLA	Xu, Shuai,et al."Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer".DOSE-RESPONSE 19.3(2021):11.