Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering

doi:10.15252/embj.201798115

CORC > 植物研究所 > 中国科学院植物研究所 > 中科院植物分子生理学重点实验室

	Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering
	Xing, Lijing ; Liu, Yan 5; Xu, Shujuan 4; Xiao, Jun 3; Wang, Bo 4; Deng, Hanwen 4; Lu, Zhuang ; Xu, Yunyuan ; Chong, Kang 2,4
刊名	EMBO JOURNAL
	2018
卷号	37 期号:19
关键词	ATX1 HKMT activity O-GlcNAcylation SEC
ISSN号	0261-4189
DOI	10.15252/embj.201798115
文献子类	Article
英文摘要	Post-translational modification of proteins by O-linked -N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc transferases (OGTs). O-GlcNAc modification of proteins regulates multiple important biological processes in metazoans. However, whether protein O-GlcNAcylation is involved in epigenetic processes during plant development is largely unknown. Here, we show that loss of function of SECRET AGENT (SEC), an OGT in Arabidopsis, leads to an early flowering phenotype. This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering. SEC activates ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1), a histone lysine methyltransferase (HKMT), through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone modification at FLC locus. SEC transfers an O-GlcNAc group on Ser947 of ATX1,which resides in the SET domain, thereby activating ATX1. Taken together, these results uncover a novel post-translational O-GlcNAc modification-mediated mechanism for regulation of HKMT activity and establish the function of O-GlcNAc signaling in epigenetic processes in plants.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
电子版国际标准刊号	1460-2075
出版地	HOBOKEN
WOS关键词	BETA-N-ACETYLGLUCOSAMINE ; TRITHORAX GROUP PROTEINS ; POLYCOMB-GROUP PROTEINS ; GROWTH REPRESSOR DELLA ; LOCUS-C ; PLANT DEVELOPMENT ; H3K4 METHYLATION ; DOMAIN PROTEIN ; COMPLEX 2 ; GLCNACYLATION
语种	英语
出版者	WILEY
WOS记录号	WOS:000446029400003
资助机构	Basic Science Center Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31788103] ; National Key Research and Development Program of China [2016YFD0101004]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/20393]
专题	中科院植物分子生理学重点实验室
作者单位	1.Natl Ctr Plant Gene Res, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Plant Cell & Chromosome Engn, Inst Genet & Dev Biol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Northeast Agr Univ, Coll Hort, Harbin, Heilongjiang, Peoples R China 5.Chinese Acad Sci, Key Lab Plant Mol Physiol, Inst Bot, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xing, Lijing,Liu, Yan,Xu, Shujuan,et al. Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering[J]. EMBO JOURNAL,2018,37(19).
APA	Xing, Lijing.,Liu, Yan.,Xu, Shujuan.,Xiao, Jun.,Wang, Bo.,...&Chong, Kang.(2018).Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering.EMBO JOURNAL,37(19).
MLA	Xing, Lijing,et al."Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering".EMBO JOURNAL 37.19(2018).