Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.

doi:10.1016/j.biocon.2017.09.011

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	Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.
	Li, Lin 4; Josef, Brinckmann A.; Liu, Bing 2; Zheng, Sihao 4; Huang, Linfang 4; Chen, Shilin 1
刊名	FRONTIERS IN PLANT SCIENCE
	2017
卷号	8
关键词	Artemisia annua artemisinin DNA barcoding ecotype ecotypic diversity
ISSN号	1664-462X
DOI	10.1016/j.biocon.2017.09.011
文献子类	Article
英文摘要	Artemisinin is the first-line drug for anti-malaria recommended by the World Health Organization (WHO). As the sole natural plant source of artemisinin, ecotypes of Artemisia annua L. vary widely in artemisinin content between nations, and China is the main producing area of A. annua. Here we present a three-dimensional evaluation on ecotypic diversity of A. annua from 12 main producing areas in China using highperformance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) method, DNA barcoding and ecological analyses. The results indicated that A. annua exhibited high ecotypic diversity. A. annua grown in the South of the Qinling Mountains-Huaihe River Line had a high artemisinin content, whereas the northern ones were low. Similar pattern was noted in the genetic diversity. The southern A. annua had high intraspecific variation in contrast to the northern A. annua. In terms of ecological analyses, humidity and sunshine time could be the major limiting ecological factors that affect the accumulation of artemisinin. This is the first reported threedimensional evaluation integrating chemical, molecular and ecological analyses of the ecotypic diversity of A. annua. The work will facilitate exploring the genetic basis of chemical variations and developing strategies for the breeding and cultivation of high quality A. annua.
学科主题	Biodiversity & Conservation ; Environmental Sciences & Ecology
出版地	LAUSANNE
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; DNA BARCODE ; GENETIC-CHARACTERIZATION ; ADAPTATION ; BIOMASS ; PROFILE ; GROWTH
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000414883000018
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473315] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2016-12M-3-015]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/22273]
专题	系统与进化植物学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Bot, Beijing, Peoples R China 2.Josef, Brinckmann A.] Sustainabil Dept, Tradit Med, Sebastopol, CA USA 3.Peking Union Med Coll, Beijing, Peoples R China 4.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China 5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Lin,Josef, Brinckmann A.,Liu, Bing,et al. Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.[J]. FRONTIERS IN PLANT SCIENCE,2017,8.
APA	Li, Lin,Josef, Brinckmann A.,Liu, Bing,Zheng, Sihao,Huang, Linfang,&Chen, Shilin.(2017).Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L..FRONTIERS IN PLANT SCIENCE,8.
MLA	Li, Lin,et al."Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.".FRONTIERS IN PLANT SCIENCE 8(2017).