Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys | |
Yan, Li5; Bai, Chen4; Zheng, Yu3; Zhou, Xiaodong2; Wan, Mingxi1; Zong, Yujin1; Chen, Shanshan2; Zhou, Yin5 | |
刊名 | FRONTIERS IN NEUROLOGY |
2021-11-17 | |
卷号 | 12 |
关键词 | super-resolution imaging ultrasound cerebral vessel microbubbles monkey |
ISSN号 | 1664-2295 |
DOI | 10.3389/fneur.2021.720320 |
产权排序 | 2 |
英文摘要 | Background: Ultrasound is ideal for displaying intracranial great vessels but not intracranial microvessels and terminal vessels. Even with contrast agents, the imaging effect is still unsatisfactory. In recent years, significant theoretical advances have been achieved in super-resolution imaging. The latest commonly used ultrafast plane-wave ultrasound Doppler imaging of the brain and microbubble-based super-resolution ultrasound imaging have been applied to the imaging of cerebral microvessels and blood flow in small animals such as mice but have not been applied to in vivo imaging of the cerebral microvessels in monkeys and larger animals. In China, preliminary research results have been obtained using super-resolution imaging in certain fields but rarely in fundamental and clinical experiments on large animals. In recent years, we have conducted a joint study with the Xi'an Jiaotong University to explore the application and performance of this new technique in the diagnosis of cerebrovascular diseases in large animals.Objective: To explore the characteristics and advantages of microbubble-based super-resolution ultrasound imaging of intracranial vessels in rhesus monkeys compared with conventional transcranial ultrasound.Methods: First, the effectiveness and feasibility of the super-resolution imaging technique were verified by modular simulation experiments. Then, the imaging parameters were adjusted based on in vitro experiments. Finally, two rhesus monkeys were used for in vivo experiments of intracranial microvessel imaging.Results: Compared with conventional plane-wave imaging, super-resolution imaging could measure the inner diameters of cerebral microvessels at a resolution of 1 mm or even 0.7 mm and extract blood flow information. In addition, it has a better signal-to-noise ratio (5.625 dB higher) and higher resolution (~30-fold higher). The results of the experiments with rhesus monkeys showed that microbubble-based super-resolution ultrasound imaging can achieve an optimal resolution at the micron level and an imaging depth >35 mm.Conclusion: Super-resolution imaging can realize the monitoring imaging of high-resolution and fast calculation of microbubbles in the process of tissue damage, providing an important experimental basis for the clinical application of non-invasive transcranial ultrasound. |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000725749000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.opt.ac.cn/handle/181661/95582] |
专题 | 西安光学精密机械研究所_瞬态光学技术国家重点实验室 |
通讯作者 | Bai, Chen; Zhou, Xiaodong |
作者单位 | 1.Xi An Jiao Tong Univ, Dept Biomed Engn, Key Lab Biomed Informat Engn, Minist Educ, Xian, Peoples R China 2.Xian Int Med Ctr, Ultrasound Diag & Treatment Ctr, Xian, Peoples R China 3.Jiaotong Univ, Xian Cent Hosp, Affiliated Hosp 3, Dept Ultrasonog, Xian, Peoples R China 4.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian, Peoples R China 5.Northwestern Polytech Univ, Inst Med Res, Xian, Peoples R China |
推荐引用方式 GB/T 7714 | Yan, Li,Bai, Chen,Zheng, Yu,et al. Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys[J]. FRONTIERS IN NEUROLOGY,2021,12. |
APA | Yan, Li.,Bai, Chen.,Zheng, Yu.,Zhou, Xiaodong.,Wan, Mingxi.,...&Zhou, Yin.(2021).Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys.FRONTIERS IN NEUROLOGY,12. |
MLA | Yan, Li,et al."Study on the Application of Super-Resolution Ultrasound for Cerebral Vessel Imaging in Rhesus Monkeys".FRONTIERS IN NEUROLOGY 12(2021). |
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