Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities

doi:10.3389/fimmu.2021.772729

	Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities
	Wu, Zaigui 1; Wang, Miaomiao 1; Liang, Guanmian 2; Jin, Pengzhen 1; Wang, Peng 1; Xu, Yuqing 1; Qian, Yeqing 1,3,4; Jiang, Xiuxiu 1; Qian, Junbin 1; Dong, Minyue 1,3,4
刊名	FRONTIERS IN IMMUNOLOGY
	2021-12-08
卷号	12
关键词	recurrent pregnancy loss decidua CyTOF embryonic chromosomal aberrations maternal immune tolerance
ISSN号	1664-3224
DOI	10.3389/fimmu.2021.772729
通讯作者	Dong, Minyue(dongmy@zju.edu.cn)
英文摘要	Recurrent pregnancy loss (RPL), especially the unexplained RPL, is associated with the disruption of maternal immune tolerance. However, little is known about the immune status at the decidua of RPL with embryonic chromosomal aberrations. Herein, mass cytometry (CyTOF) was used to interrogate the immune atlas at the decidua which was obtained from 15 RPL women-six with normal chromosome and nine with chromosomal aberrations-and five controls. The total frequency of CCR2(-)CD11c(high) macrophages increased, while CD39(high) NK cells and CCR2(-)CD11c(low) macrophages decrease significantly in RPL when RPLs were stratified, compared with controls. Pro-inflammatory subsets of CD11c(high) macrophages increased, while less pro-inflammatory or suppressive subsets decreased statistically in RPL decidua whenever RPLs were stratified or not. However, CD11c(high) NK and CD161(high)CD8(+) T cells increased only in RPL with normal chromosome, while the inactivated and naive CD8(+)/CD4(+) T cells were enriched only in RPL with chromosomal aberrations. A pro-inflammatory signature is observed in RPL decidua; however, differences exist between RPL with and without chromosomal abnormalities.
资助项目	Natural Science Foundation of China[81370726] ; Key Research and Development Plan of Zhejiang Province[2019C03025] ; Natural Science Foundation of Zhejiang Province[LQ19H040011] ; Program for Education Department of Zhejiang Province[Y201941996] ; Zhejiang Province Medical and Health Technology Project[2019KY431] ; Zhejiang Province Medical and Health Technology Project[2020KY616]
WOS关键词	CELLS ; EXPRESSION ; SUBSET ; CD161
WOS研究方向	Immunology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000732529800001
资助机构	Natural Science Foundation of China ; Key Research and Development Plan of Zhejiang Province ; Natural Science Foundation of Zhejiang Province ; Program for Education Department of Zhejiang Province ; Zhejiang Province Medical and Health Technology Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126896]
专题	中国科学院合肥物质科学研究院
通讯作者	Dong, Minyue
作者单位	1.Zhejiang Univ Sch Med, Womens Hosp, Sch Med, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 3.Key Lab Womens Reprod Hlth Zhejiang Prov, Hangzhou, Peoples R China 4.Zhejiang Univ, Key Lab Reprod Genet, Minist Educ, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zaigui,Wang, Miaomiao,Liang, Guanmian,et al. Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities[J]. FRONTIERS IN IMMUNOLOGY,2021,12.
APA	Wu, Zaigui.,Wang, Miaomiao.,Liang, Guanmian.,Jin, Pengzhen.,Wang, Peng.,...&Dong, Minyue.(2021).Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities.FRONTIERS IN IMMUNOLOGY,12.
MLA	Wu, Zaigui,et al."Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities".FRONTIERS IN IMMUNOLOGY 12(2021).