Current status of total neoadjuvant therapy for locally advanced rectal cancer

doi:10.1111/ajco.13640

	Current status of total neoadjuvant therapy for locally advanced rectal cancer
	Feng, Wei 1,7; Yu, Bin 5,6; Zhang, Zhenya 5,6; Li, Juan 2,3,4,5; Wang, Yuxiang 2,3,4,5
刊名	ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
	2021-11-24
关键词	chemoradiation therapy chemotherapy disease-free survival (DFS) pathological complete response (pCR) rectal cancer sphincter preservation
ISSN号	1743-7555
DOI	10.1111/ajco.13640
通讯作者	Wang, Yuxiang(wyxhbs69@163.com)
英文摘要	Neoadjuvant chemoradiotherapy (nCRT) plus total mesorectal excision (TME) has been the standard regimen for treatment of patients with locally advanced rectal cancer (LARC), because it significantly reduces the rate of local recurrence and enables sphincter preservation. However, distant metastasis remains the major reason for treatment failure, and the value of postoperative chemotherapy is still controversial. Recent studies have examined the use of total neoadjuvant therapy (TNT), defined as induction and/or consolidation chemotherapy (CONCT) with radiotherapy (RT) or nCRT prior to surgery. The results indicated that TNT may increase the rates of chemotherapy compliance and pathological complete response (pCR), and probably improve the success rate of sphincter preservation surgery. TNT may also improve disease-free survival and overall survival, and even reduce the rate of relapse. Here, we critically appraise the existing literature on three different TNT schemes used for LARC patients.
WOS关键词	TOTAL MESORECTAL EXCISION ; PHASE-III TRIAL ; HIGH-RISK ; PREOPERATIVE CHEMORADIOTHERAPY ; OPEN-LABEL ; INDUCTION CHEMOTHERAPY ; ADJUVANT CHEMOTHERAPY ; RADIATION-THERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; CONCOMITANT CHEMORADIOTHERAPY
WOS研究方向	Oncology
语种	英语
出版者	WILEY
WOS记录号	WOS:000721908300001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/126666]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yuxiang
作者单位	1.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 2.Hebei Med Univ, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China 3.Hebei Clin Res Ctr Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China 4.Hebei Med Univ, Dept Radiat Oncol, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 5.Hebei Prov Tumor Hosp, Shijiazhuang 050011, Hebei, Peoples R China 6.Hebei Med Univ, Dept Surg 2, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 7.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Feng, Wei,Yu, Bin,Zhang, Zhenya,et al. Current status of total neoadjuvant therapy for locally advanced rectal cancer[J]. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY,2021.
APA	Feng, Wei,Yu, Bin,Zhang, Zhenya,Li, Juan,&Wang, Yuxiang.(2021).Current status of total neoadjuvant therapy for locally advanced rectal cancer.ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY.
MLA	Feng, Wei,et al."Current status of total neoadjuvant therapy for locally advanced rectal cancer".ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2021).