Effects of exercise on flow characteristics in human carotids

doi:10.1063/5.0078061

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Effects of exercise on flow characteristics in human carotids
	He, Xinyi 2,3; Yang, Xiaolei 1,2
刊名	PHYSICS OF FLUIDS
	2022
卷号	34 期号:1 页码:16
ISSN号	1070-6631
DOI	10.1063/5.0078061
通讯作者	Yang, Xiaolei(xyang@imech.ac.cn)
英文摘要	Carotid is one of the focal regions prone to atherosclerosis. Previous studies have shown that hemodynamics plays an important role in the initiation and formation of atherosclerosis plaques. In this work, we numerically investigate the flow patterns in two carotids with different flares and proximal curvatures under inflows from three age groups with/without exercise. The simulation results show that the effects of exercising on the carotid flow and wall shear stress are different at different time instants and for different age groups. As for the oscillatory shear index, exercise does not have significant effects. The effects of inflow waveforms on the reversed flow volume are also examined. For the carotid C1 with low flare and high proximal curvature, it is found that exercising increases and decreases the reversed flow volume for young and senior people, respectively. For middle-aged people, on the other hand, the reversed flow volume is increased and decreased in the middle of the sinus and near the bifurcation, respectively, for the carotid C1. For the carotid C2 with high flare and low curvature, on the other hand, it is found that exercising increases the reversed flow volume for all age groups. This work suggests that the effects of exercise on atherosclerosis should be evaluated by fully considering patient-specific geometries and ages.
资助项目	NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics[11988102]
WOS关键词	ENDOTHELIAL GENE-EXPRESSION ; FLUID-STRUCTURE INTERACTION ; EPIGENETIC DNA METHYLATION ; IMMERSED BOUNDARY METHOD ; NITRIC-OXIDE PRODUCTION ; LARGE-EDDY SIMULATION ; SHEAR-STRESS ; BIFURCATION GEOMETRY ; ATHEROSCLEROSIS ; ARTERY
WOS研究方向	Mechanics ; Physics
语种	英语
WOS记录号	WOS:000753213600006
资助机构	NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/88602]
专题	力学研究所_非线性力学国家重点实验室
通讯作者	Yang, Xiaolei
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 3.Nanchang Hangkong Univ, Coll Aircraft Engn, Nanchang 330063, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	He, Xinyi,Yang, Xiaolei. Effects of exercise on flow characteristics in human carotids[J]. PHYSICS OF FLUIDS,2022,34(1):16.
APA	He, Xinyi,&Yang, Xiaolei.(2022).Effects of exercise on flow characteristics in human carotids.PHYSICS OF FLUIDS,34(1),16.
MLA	He, Xinyi,et al."Effects of exercise on flow characteristics in human carotids".PHYSICS OF FLUIDS 34.1(2022):16.