Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha)

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	Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha)
	Hu, Tao 2; Li, Dongxia 2; Wang, Jun 2; Wang, Qingqing 2; Liang, Yangui 2,3; Su, Yanlei 3; Ma, Guanghui 2; Su, Zhiguo 2; Wang, Shihua 1
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
	2012-12-01
卷号	1820 期号:12 页码:2044-2051
关键词	PEGylation Hemoglobin-based oxygen carrier Propylbenzmethylation Hemoglobin Tetramer stability
ISSN号	0304-4165
通讯作者	Wang, SH
英文摘要	Background: Hemoglobin (Hb)-based oxygen carriers (HBOCs) are potential pharmaceutical agents that can be used in surgery or emergency medicine. PEGylation can modulate the vasoactivity of Hb and is a widely used approach to develop HBOCs. However, PEGylation can significantly enhance the tetramer-dimer dissociation of Hb, which may perturb the structure of Hb and increase its observed adverse effect. Thus, it is necessary to increase the tetramer stability of the PEGylated Hb.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	RECOMBINANT HUMAN HEMOGLOBIN ; HEME-GLOBIN LINKAGE ; OXYGEN CARRIERS ; BLOOD SUBSTITUTES ; TREMATOMUS-BERNACCHII ; FUNCTIONAL-PROPERTIES ; PEG-HB ; STAPHYLOKINASE ; COOPERATIVITY ; DISSOCIATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000311004000023
公开日期	2013-10-11
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/3163]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Hu, Tao,Li, Dongxia,Wang, Jun,et al. Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha)[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2012,1820(12):2044-2051.
APA	Hu, Tao.,Li, Dongxia.,Wang, Jun.,Wang, Qingqing.,Liang, Yangui.,...&Wang, Shihua.(2012).Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha).BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1820(12),2044-2051.
MLA	Hu, Tao,et al."Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha)".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1820.12(2012):2044-2051.