Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization

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	Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization
	Ji KG(纪克攻) ; Zhu HT(祝海涛) ; Yang F(杨芳) ; Ali Shaukat ; Xia XF(夏晓峰) ; Yang YF(杨艳芳) ; Liu XY(刘雪原) ; Liang YM(梁永民)
刊名	Journal of Organic Chemistry
	2010
卷号	75 页码:5670-5678
ISSN号	0022-3263
通讯作者	梁永民
中文摘要	Highly substituted dihalogenated dihydrofurans, dihydropyrroles, and dihydro-2H-pyrans bearingalkyl, vinyl, aryl, and heteroaryl moieties can be prepared in good to excellent yields (up to 99%) byallowing 1,4-butyne-diol, 4-aminobut-2-yn-1-ol, and pent-2-yne-1,5-diol derivatives to react withdifferent electrophiles (I2, IBr, and ICl) at room temperature. Both halogen atoms generated fromelectrophiles were used effectively. The resulting halides can be further exploited by using palladium-catalyzed coupling reactions. The presence of trace amount of water is essential for this electrophilic cyclization.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	the NSF (NSF-20732002, NSF-2087205, NSF-20090443);the Fundamental Research Funds for the Central Universities
语种	英语
WOS记录号	WOS:000280798900025
公开日期	2013-10-15
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/3951]
专题	兰州化学物理研究所_固体润滑国家重点实验室
推荐引用方式 GB/T 7714	Ji KG,Zhu HT,Yang F,et al. Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization[J]. Journal of Organic Chemistry,2010,75:5670-5678.
APA	纪克攻.,祝海涛.,杨芳.,Ali Shaukat.,夏晓峰.,...&梁永民.(2010).Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization.Journal of Organic Chemistry,75,5670-5678.
MLA	纪克攻,et al."Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization".Journal of Organic Chemistry 75(2010):5670-5678.