Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives

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	Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives
	Lin L(林利) ; Xu Fu ; Ma XJ(马晓娟) ; Zhang JL(张金龙) ; Wang R(王锐)
刊名	Synlett
	2012
卷号	23 页码:2559-2563
关键词	unnatural α-amino acids peptides regioselectivity asymmetric synthesis chiral auxiliaries
ISSN号	0936-5214
通讯作者	王锐
中文摘要	This work provides a general approach to unnatural chiral N-tert-butanesulfinyl α-amino acid synthesis with high yields and excellent diastereoselectivities (dr up to 98:2). The asymmetric addition of organometallic reagents to N-tert-butylsulfinyl imino acetate proceeded with excellent diastereo- and regioselectivities even on a 10 mmol scale. The sterically constrained 2′,6′-dimethyltyrosine (Dmt) derivative was also readily prepared from commercially available and inexpensive starting materials through simple steps.
学科主题	物理化学
收录类别	SCI
资助信息	NSFC (nos. 21002043;20932003;90813012);the Key National S & T Program ‘Major New Drug Development’ of the Ministry of Science and Technology (2012ZX09504001-003)
语种	英语
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/3877]
专题	兰州化学物理研究所_OSSO国家重点实验室
推荐引用方式 GB/T 7714	Lin L,Xu Fu,Ma XJ,et al. Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives[J]. Synlett,2012,23:2559-2563.
APA	林利,Xu Fu,马晓娟,张金龙,&王锐.(2012).Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives.Synlett,23,2559-2563.
MLA	林利,et al."Unnatural Chiral N-tert-Butanesulfinyl α-Amino Acid Synthesis; A General Synthetic Strategy to N-Boc-Phenylalanine Analogue Alternatives".Synlett 23(2012):2559-2563.