Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents

doi:10.5582/bst.2021.01140

	Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents
	Wang, Wenwen 1,2,3; Zhang, Zijia 1,2; Deng, Yanping 1,2; Yang, Zhixin 1,2; Hou, Jinjun 1,2; Long, Huali 1,2; Lei, Min 1,2; Wu, Wanying 1,2
刊名	BIOSCIENCE TRENDS
	2021-08-01
卷号	15 期号:4 页码:231-239
关键词	Neuroinflammation Shenqi Fuzheng Injection (SFI) Arginase 1 (Arg1) Transforming growth factor beta-1 (Tgfb1) microglia
ISSN号	1881-7815
DOI	10.5582/bst.2021.01140
通讯作者	Lei, Min(mlei@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要	Enhancement of alternative activation (M2) in microglia is a promising therapeutic target for microglia-mediated neuroinflammation. Shenqi Fuzheng Injection (SFI) is a clinical adjuvant treatment for cancer to reduce the side effects during cancer treatment, including boosting mood and improving appetite. However, the mechanism of SFI's effects on central symptoms is not clear. Therefore, using arginase 1 (Arg1) and transforming growth beta-1 (Tgfb1) as markers for M2 microglia activation, we found that compounds 1, 5, 12, 14, and 15 are the major M2-promoting constituents in SFI, which significantly upregulated Arg1 or Tgfb1 gene expression. Our results suggested that these compounds in SFI may promote M2 microglial activation and have potential uses in modulating microglial activation and alleviating neuroinflammation.
资助项目	Youth Program of National Natural Science Foundation of China[82003939] ; Key Research and Development Projects in Guangdong Province of China[2020B1111110001]
WOS关键词	INJURY ; NEUROGENESIS ; MICROGLIA ; PATHWAY ; MICE
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	IRCA-BSSA
WOS记录号	WOS:000696511400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297860]
专题	中国科学院上海药物研究所
通讯作者	Lei, Min; Wu, Wanying
作者单位	1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Heilongjiang Univ Chinese Med, Harbin, Heilongjiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wenwen,Zhang, Zijia,Deng, Yanping,et al. Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents[J]. BIOSCIENCE TRENDS,2021,15(4):231-239.
APA	Wang, Wenwen.,Zhang, Zijia.,Deng, Yanping.,Yang, Zhixin.,Hou, Jinjun.,...&Wu, Wanying.(2021).Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents.BIOSCIENCE TRENDS,15(4),231-239.
MLA	Wang, Wenwen,et al."Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents".BIOSCIENCE TRENDS 15.4(2021):231-239.