Metal-organic frameworks for advanced drug delivery | |
He, Siyu1,2; Wu, Li1; Li, Xue3; Sun, Hongyu1; Xiong, Ting1,4; Liu, Jie5; Huang, Chengxi1,2; Xu, Huipeng1; Sun, Huimin6; Chen, Weidong5 | |
刊名 | ACTA PHARMACEUTICA SINICA B |
2021-08-01 | |
卷号 | 11期号:8页码:2362-2395 |
关键词 | Metal-organic frameworks Drug loading Drug delivery systems Synthesis and characterization Diseases therapy Pharmaceutics Biopharmaceutics Biosafety |
ISSN号 | 2211-3835 |
DOI | 10.1016/j.apsb.2021.03.019 |
通讯作者 | Chen, Weidong(anzhongdong@126.com) ; Gref, Ruxandra(ruxandra.gref@u-psud.fr) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
英文摘要 | Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
资助项目 | National Key R&D Program of China[2020YFE0201700] ; National Nature Science Foundation of China[81773645] ; French National Research Agency (ANR), France (France)[ANR-10-LABX-0035] |
WOS关键词 | ONE-POT SYNTHESIS ; ZEOLITIC IMIDAZOLATE FRAMEWORKS ; ROOM-TEMPERATURE SYNTHESIS ; SOLVENT-FREE SYNTHESIS ; CONTROLLED-RELEASE ; MOF NANOPARTICLES ; MICROWAVE SYNTHESIS ; MAGNETIC-RESONANCE ; CD-MOF ; COORDINATION POLYMERS |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
WOS记录号 | WOS:000692095800001 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/297795] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Chen, Weidong; Gref, Ruxandra; Zhang, Jiwen |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Paris Saclay, Inst Sci Mol Orsay, F-91400 Orsay, France 4.Jiangxi Univ Tradit Chinese Med, Key Lab Modern Chinese Med Preparat, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China 5.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei 230012, Peoples R China 6.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China |
推荐引用方式 GB/T 7714 | He, Siyu,Wu, Li,Li, Xue,et al. Metal-organic frameworks for advanced drug delivery[J]. ACTA PHARMACEUTICA SINICA B,2021,11(8):2362-2395. |
APA | He, Siyu.,Wu, Li.,Li, Xue.,Sun, Hongyu.,Xiong, Ting.,...&Zhang, Jiwen.(2021).Metal-organic frameworks for advanced drug delivery.ACTA PHARMACEUTICA SINICA B,11(8),2362-2395. |
MLA | He, Siyu,et al."Metal-organic frameworks for advanced drug delivery".ACTA PHARMACEUTICA SINICA B 11.8(2021):2362-2395. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论