Honokiol: A naturally occurring lignan with pleiotropic bioactivities

doi:10.1016/S1875-5364(21)60047-X

	Honokiol: A naturally occurring lignan with pleiotropic bioactivities
	Chen Cheng 1; Zhang Qing-Wen 1; Ye Yang 2; Lin Li-Gen 1
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2021-07-01
卷号	19 期号:7 页码:481-490
关键词	Honokiol Natural sources Ethnopharmacological uses Physicochemical properties Bioactivities Clinical trials
ISSN号	2095-6975
DOI	10.1016/S1875-5364(21)60047-X
通讯作者	Lin Li-Gen(ligenl@um.edu.mo)
英文摘要	Honokiol is the dominant biphenolic compound isolated from the Magnolia tree, and has long been considered as the active constituent of the traditional Chinese herb, 'Houpo', which is widely used to treat symptoms due to 'stagnation of qi'. Pharma-cological studies have shown that honokiol possesses a wide range of bioactivities without obvious toxicity. Honokiol protects the liver, kidneys, nervous system, and cardiovascular system through reducing oxidative stress and relieving inflammation. Moreover, honokiol shows anti-diabetic property through enhancing insulin sensitivity, and anti-obese property through promoting browning of adipocytes. In vivo and in vitro studies indicated that honokiol functions as an anti-cancer agent through multiple mechanisms: inhibiting angiogenesis, promoting cell apoptosis, and regulating cell cycle. A variety of therapeutic effects of honokiol may be associated with its physiochemical properties, which make honokiol readily cross the blood brain barrier and the blood-cerebrospinal fluid barrier, with high bioavailability. In the future, more clinical researches on honokiol are needed to fully authenticate its therapeutic values.
资助项目	National Natural Science Foundation of China[81872754] ; Science and Technology Development Fund, Macau SAR[FDCT 0031/2019/A1] ; University of Macau[MYRG2017-00109-ICMS] ; University of Macau[MYRG2018-00037-ICMS]
WOS关键词	ANTIDEPRESSANT-LIKE SYNERGISM ; INDUCED CELLULAR-RESPONSES ; ACTIVATED PROTEIN-KINASE ; ALCOHOLIC FATTY LIVER ; KAPPA-B ACTIVATION ; MAGNOLIA-OFFICINALIS ; IN-VITRO ; INSULIN-RESISTANCE ; SIGNALING PATHWAY ; OXIDATIVE STRESS
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000671867000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296920]
专题	中国科学院上海药物研究所
通讯作者	Lin Li-Gen
作者单位	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen Cheng,Zhang Qing-Wen,Ye Yang,et al. Honokiol: A naturally occurring lignan with pleiotropic bioactivities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2021,19(7):481-490.
APA	Chen Cheng,Zhang Qing-Wen,Ye Yang,&Lin Li-Gen.(2021).Honokiol: A naturally occurring lignan with pleiotropic bioactivities.CHINESE JOURNAL OF NATURAL MEDICINES,19(7),481-490.
MLA	Chen Cheng,et al."Honokiol: A naturally occurring lignan with pleiotropic bioactivities".CHINESE JOURNAL OF NATURAL MEDICINES 19.7(2021):481-490.