3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院饮用水科学与技术重点实验室

	3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes)
	Liang, Mengmeng; Yan, Saihong; Chen, Rui; Hong, Xiangsheng; Zha, Jinmiao
刊名	CHEMOSPHERE
	2020-06
卷号	249 页码:1-9
关键词	UV filter Development toxicity Endocrine disruption Histopathology Transcripts
ISSN号	0045-6535
英文摘要	To assess the toxic effects of 3-(4-Methylbenzylidene) camphor (4-MBC) at environmentally relevant concentrations on the reproduction and development of Japanese medaka (Oryzias latipes), adult paired medaka (F0) were exposed to 5, 50, and 500 mu g/L 4-MBC for 28 d in the current study. The fecundity and fertility were significantly decreased at 500 mu g/L 4-MBC (p < 0.05). Histological observations showed that spermatogenesis in F0 males was significantly inhibited at 50 and 500 mu g/L 4-MBC, similar to the effects obtained with all treatments of plasma 11-ketotestosterone (p < 0.05). Moreover, the plasma vitellogenin and estradiol levels in F0 females were significantly increased at 5 mu g/L 4-MBC (p < 0.05). All the transcripts of hypothalamic-pituitary-gonadal (HPG) axis-related genes tested in the brains and gonads of males were significantly increased at all treatments, similar to the effects obtained for er alpha, er beta and vtg in the livers and in contrast to those found for ar alpha in the livers (p < 0.05). Equal numbers of embryos were exposed to tap water and 4-MBC solutions. Significantly increased times to hatching, decreased hatching rates and decreased body lengths at 14-day post-hatching (dph) were obtained at 500 mu g/L 4-MBC treatment (p < 0.05). The cumulative death rates at 14 dph were significantly increased with all the treatments (p < 0.05). Therefore, our results showed that long-term exposure to 50 and 500 mu g/L 4-MBC causes reproductive and developmental toxicity and thus provide new insight into antiandrogenicity and the mechanism of 4-MBC in Japanese medaka. (C) 2020 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/45225]
专题	生态环境研究中心_中国科学院饮用水科学与技术重点实验室
推荐引用方式 GB/T 7714	Liang, Mengmeng,Yan, Saihong,Chen, Rui,et al. 3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes)[J]. CHEMOSPHERE,2020,249:1-9.
APA	Liang, Mengmeng,Yan, Saihong,Chen, Rui,Hong, Xiangsheng,&Zha, Jinmiao.(2020).3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes).CHEMOSPHERE,249,1-9.
MLA	Liang, Mengmeng,et al."3-(4-Methylbenzylidene) camphor induced reproduction toxicity and antiandrogenicity in Japanese medaka (Oryzias latipes)".CHEMOSPHERE 249(2020):1-9.