Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40

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	Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40
	Qin, Wei-Ping; Cao, Lin-Ying; Li, Chuan-Hai; Guo, Liang-Hong; Colbourne, John; Ren, Xiao-Min
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2020-03-17
卷号	54 期号:6 页码:3428-3436
ISSN号	0013-936X
英文摘要	The potential causal relationship between exposure to environmental contaminants and diabetes is troubling. Exposure of perfluoroalkyl substances (PFASs) is found to be associated with hyperinsulinemia and the enhancement of insulin secretion by islet beta cells in humans, but the underlying mechanism is still unclear. Here, by combining in vivo studies with both wild type and gene knockout mice and in vitro studies with mouse islet beta cells (beta-TC-6), we demonstrated clearly that 1 h exposure of perfluorooctanesulfonate (PFOS) stimulated insulin secretion and intracellular calcium level by activating G protein-coupled receptor 40 (GPR40), a vital free fatty acid regulated membrane receptor on islet beta cells. We further showed that the observed effects of PFASs on the mouse model may also exist in humans by investigating the molecular binding interaction of PFASs with human GPR40. We thus provided evidence for a novel mechanism for how insulin-secretion is disrupted by PFASs in humans.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44769]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Qin, Wei-Ping,Cao, Lin-Ying,Li, Chuan-Hai,et al. Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(6):3428-3436.
APA	Qin, Wei-Ping,Cao, Lin-Ying,Li, Chuan-Hai,Guo, Liang-Hong,Colbourne, John,&Ren, Xiao-Min.(2020).Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(6),3428-3436.
MLA	Qin, Wei-Ping,et al."Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.6(2020):3428-3436.