Paraben concentrations in human fingernail and its association with personal care product use

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Paraben concentrations in human fingernail and its association with personal care product use
	Li, Chao; Cui, Xinyi; Chen, Yi; Liao, Chunyang
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2020-10-01
卷号	202 页码:1-12
关键词	Parabens Fingernail Personal care products Human exposure
ISSN号	0147-6513
英文摘要	Parabens are used as antimicrobial preservatives in a range of consumer products. However, very limited information is available about the association between use of personal care products and paraben burden in human tissues. Accumulation of parabens in some non-destructive biomarkers (such as human fingernail) is essential for paraben biomonitoring. In this study, 50 human fingernail samples were collected from Nanjing, China. A subset of participants (n = 32) also provided their face cream samples (as the representative of personal care products). Six parabens, including methyl-(MeP), ethyl-(EtP), propyl-(PrP), butyl-(BuP), heptyl-(HeP), and benzylparabens (BzP), together with their major metabolites were measured in the fingernail and face cream samples. Total concentrations of parabens and their major metabolites were 39.9-27400 ng/g in fingernails. MeP, PrP and EtP were the three dominant parabens in fingernails with median values of 3140, 1290, and 127 ng/g, respectively. Significantly higher levels in female fingernails than those in male fingernails were observed for MeP, PrP, EtP, BuP, and the MeP metabolite (methyl protocatechuate, OH-MeP) (p < 0.05). Adult fingernails contained greater concentrations of MeP and PrP than juvenile fingernails (p < 0.05). Positive correlations were observed for EtP (R = 0.36, p < 0.05) and BuP (R = 0.48, p = 0.008) concentrations between the fingernail and face cream samples. Our work is a preliminary study trying to explore the quantitative relationship between paraben concentrations in human body and use of personal care products. The result here provides a direct evidence that use of personal care products is one of the major sources for human exposure to parabens.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44768]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Chao,Cui, Xinyi,Chen, Yi,et al. Paraben concentrations in human fingernail and its association with personal care product use[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,202:1-12.
APA	Li, Chao,Cui, Xinyi,Chen, Yi,&Liao, Chunyang.(2020).Paraben concentrations in human fingernail and its association with personal care product use.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,202,1-12.
MLA	Li, Chao,et al."Paraben concentrations in human fingernail and its association with personal care product use".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 202(2020):1-12.