Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-beta Signaling-Dependent Epithelial-Mesenchymal Transition

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-beta Signaling-Dependent Epithelial-Mesenchymal Transition
	Zhu, Jianqiang; Li, Bin; Xu, Ming; Liu, Rui; Xia, Tian; Zhang, Zhihong; Xu, Yong; Liu, Sijin
刊名	ACS NANO
	2020-01
卷号	14 期号:1 页码:818-827
关键词	graphene oxide metastasis TGF-beta receptor Smad2/3 epithelial-mesenchymal transition
ISSN号	1936-0851
英文摘要	Nanomedicines are being developed to treat diverse diseases; however, inadvertent or unintended health effects have to be considered, especially for those targeting cancers. For cancers, occurrence of metastasis hints an advanced phase of cancer progression, and nanomedicines per se should be evaluated for their effects on existing metastatic tumors and triggering metastases. Graphene-based 2D nanomaterials, such as graphene oxide (GO), due to its unique characteristics, have been extensively studied for biomedical applications including cancer therapy. However, the potential effect of GO on metastasis has not been determined yet. Herein, we found that low-dose GO could induce significant morphological and structural changes of the cellular membrane within cancer cells, suggesting an epithelial-mesenchymal transition (EMT), with enhanced invasion/migration and the alterations of representative EMT indicators in GO-treated cells. These changes resulted in enhanced lung metastasis of cancer cells in various metastasis models. The mechanistic investigations unveiled that GO increased the protein levels of the TGF-beta receptor, leading to a constitutively activated TGF-beta-Smad2/3 signaling pathway that drives the EMT. Collectively, our findings enhance the understanding of the unintended side and detrimental effects of GO nanosheets in increasing the progression of metastatic tumors. Thus, the likelihood of pro-EMT effects upon low-dose GO exposure should be considered when developing GO nanomedicines.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44701]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Jianqiang,Li, Bin,Xu, Ming,et al. Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-beta Signaling-Dependent Epithelial-Mesenchymal Transition[J]. ACS NANO,2020,14(1):818-827.
APA	Zhu, Jianqiang.,Li, Bin.,Xu, Ming.,Liu, Rui.,Xia, Tian.,...&Liu, Sijin.(2020).Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-beta Signaling-Dependent Epithelial-Mesenchymal Transition.ACS NANO,14(1),818-827.
MLA	Zhu, Jianqiang,et al."Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF-beta Signaling-Dependent Epithelial-Mesenchymal Transition".ACS NANO 14.1(2020):818-827.