Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice
	Shan, Qiuli; Chen, Ningning; Liu, Wei; Qu, Fan; Chen, Anhui
刊名	ENVIRONMENTAL POLLUTION
	2020-08
卷号	263 页码:1-10
关键词	NAFLD PCB 156 Transcriptomics Lipid accumulation Oxidative stress
ISSN号	0269-7491
英文摘要	Previous in vitro studies have indicated that 2,3,3'4,4'5-hexachlorobiphenyl (PCB 156) may be a new contributor to metabolic disruption and may further cause the occurrence of nonalcoholic fatty liver disease (NAFLD). However, no study has clarified the specific contributions of PCB 156 to NAFLD progression by constructing an in vivo model. Herein, we evaluated the effects of PCB 156 treatment (55 mg/kg, i.p.) on the livers of C57BL/6 mice fed a control diet (CD) or a high-fat diet (HFD). The results showed that PCB 156 administration increased intra-abdominal fat mass, hepatic lipid levels and dyslipidemia in the CD-fed group and aggravated NAFLD in HFD-fed group. By using transcriptomics studies and biological methods, we found that the genes expression involved in lipid metabolism pathways, such as lipogenesis, lipid accumulation and lipid beta-oxidation, was greatly altered in liver tissues exposed to PCB 156. In addition, the cytochrome P450 pathway, peroxisome proliferator-activated receptors (PPARs) and the glutathione metabolism pathway were significantly activated following exposure to PCB 156. Furthermore, PCB 156 exposure increased serum transaminase levels and lipid peroxidation, and the redox-related genes were significantly dysregulated in liver tissue. In conclusion, our data suggested that PCB 156 could promote NAFLD development by altering the expression of genes related to lipid metabolism and inducing oxidative stress. (c) 2020 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44683]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Shan, Qiuli,Chen, Ningning,Liu, Wei,et al. Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice[J]. ENVIRONMENTAL POLLUTION,2020,263:1-10.
APA	Shan, Qiuli,Chen, Ningning,Liu, Wei,Qu, Fan,&Chen, Anhui.(2020).Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice.ENVIRONMENTAL POLLUTION,263,1-10.
MLA	Shan, Qiuli,et al."Exposure to 2,3,3 ',4,4 ',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice".ENVIRONMENTAL POLLUTION 263(2020):1-10.