Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes
	Liu, Qun S.; Sun, Zhendong; Ren, Xiaomin; Ren, Zhihua; Liu, Aifeng; Zhang, Jianqing; Zhou, Qunfang; Jiang, Guibin
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2020-05-19
卷号	54 期号:10 页码:6262-6271
ISSN号	0013-936X
英文摘要	Tetrabromobisphenol A (TBBPA), the most widely used brominated flame retardant, is reported to potentially possess risks in inducing obesity or obesity-related metabolic diseases. Considering the increasing environmental contamination of TBBPA analogues and their high structural similarities to the parent compound, whether they could influence adipogenesis or not remains to be elucidated. In this study, two of the most prevalent TBBPA derivatives [i.e., TBBPA bis(allyl ether) (TBBPA-BAE) and TBBPA bis(2,3-dibromopropyl ether) (TBBPA-BDBPE)] and their byproducts [i.e., TBBPA mono(allyl ether) (TBBPA-MAE) and TBBPA mono(2,3-dibromopropyl ether) (TBBPA-MDBPE)], together with TBBPA, were screened for their capacities in activating peroxisome proliferator-activated receptor-gamma (PPAR gamma) and glucocorticoid receptor (GR), the key nuclear receptors involved in adipogenesis, and their structure-related effects on differentiation of 3T3-L1 preadipocytes were explored. The results indicated that the binding affinities of TBBPA and its analogues for the PPAR gamma ligand-binding domain (PPAR gamma-LBD) and GR, as well as their effects on PPAR gamma transactivation, followed the order of TBBPA > TBBPA-MAE > TBBPA-MDBPE > TBBPA-BAE, TBBPA-BDBPE. Nevertheless, TBBPA-MAE and TBBPA-MDBPE showed higher potentials in promoting adipogenesis in 3T3-L1 cells than did TBBPA, as evidenced by intracellular triglyceride contents and adipogenic biomarkers at both protein and transcriptional levels. The etherified group at position 4 of TBBPA phenolic rings was crucial in chemical-induced adipogenic effects, which was related with the recruitment of PPAR gamma and GR-mediated networks and some other unidentified signaling pathways. The findings on the disturbance of TBBPA analogues on adipogenesis revealed their potential risk in causing obesity and other lipid metabolism-related human health concerns.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44631]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Liu, Qun S.,Sun, Zhendong,Ren, Xiaomin,et al. Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(10):6262-6271.
APA	Liu, Qun S..,Sun, Zhendong.,Ren, Xiaomin.,Ren, Zhihua.,Liu, Aifeng.,...&Jiang, Guibin.(2020).Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(10),6262-6271.
MLA	Liu, Qun S.,et al."Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.10(2020):6262-6271.