Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences

doi:10.3390/md19070366

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences
	Hao, Wentong 1,2,3; Li, Kecheng 1,2; Ma, Yuzhen 1,2; Li, Rongfeng 1,2; Xing, Ronge 1,2; Yu, Huahua 1,2; Li, Pengcheng 1,2
刊名	MARINE DRUGS
	2021-07-01
卷号	19 期号:7 页码:15
关键词	chitosan dimers sequence separation biological method antioxidant activity
DOI	10.3390/md19070366
通讯作者	Li, Kecheng(lkc@qdio.ac.cn) ; Xing, Ronge(xingronge@qdio.ac.cn)
英文摘要	As a popular marine saccharide, chitooligosaccharides (COS) has been proven to have good antioxidant activity. Its antioxidant effect is closely related to its degree of polymerization, degree of acetylation and sequence. However, the specific structure-activity relationship remains unclear. In this study, three chitosan dimers with different sequences were obtained by the separation and enzymatic method, and the antioxidant activity of all four chitosan dimers were studied. The effect of COS sequence on its antioxidant activity was revealed for the first time. The amino group at the reducing end plays a vital role in scavenging superoxide radicals and in the reducing power of the chitosan dimer. At the same time, we found that the fully deacetylated chitosan dimer DD showed the strongest DPPH scavenging activity. When the amino groups of the chitosan dimer were acetylated, it showed better activity in scavenging hydroxyl radicals. Research on COS sequences opens up a new path for the study of COS, and is more conducive to the investigation of its mechanism.
资助项目	National Natural Science Foundation of China[41976096] ; National Key R&D Program of China[2018YFC0311305] ; Key Research and Development Program of Shandong Province[2019YYSP028] ; Foundation for Huiquan Young Scholar of Institute of Oceanology, Chinese Academy of Sciences[E12505101Q]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000676177200001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/175776]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Kecheng; Xing, Ronge
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hao, Wentong,Li, Kecheng,Ma, Yuzhen,et al. Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences[J]. MARINE DRUGS,2021,19(7):15.
APA	Hao, Wentong.,Li, Kecheng.,Ma, Yuzhen.,Li, Rongfeng.,Xing, Ronge.,...&Li, Pengcheng.(2021).Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences.MARINE DRUGS,19(7),15.
MLA	Hao, Wentong,et al."Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences".MARINE DRUGS 19.7(2021):15.