Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides

	Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides
	Bai, Shiyang 1,2; Li, Bo 1; Peng, Juan 1,2; Zhang, Xiaoming 1,2; Yang, Qihua 1; Li, Can 1
刊名	chemical science
	2012
卷号	3 期号:9 页码:2864-2867
通讯作者	杨启华 ; 李灿
产权排序	1, 1
英文摘要	cr(salen) catalyzed kinetic resolution of terminal epoxides via asymmetric ring opening (aro) with tmsn3 is an important approach for the synthesis of enantiopure 1,2-amino alcohols, however, the high catalyst usage amount (1-2 mol%) impedes its practical applications. an efficient solid nanoreactor was constructed by encapsulation of cr(salen) and pyridine in the nanocages of mesoporous silica. this solid nanoreactor exhibits high activity (tof: 1325 h(-1)) and high enantioselectivity (91% ee) for the kinetic resolution of 1,2-epoxyhexane via aro with tmsn3 at a catalyst concentration as low as 0.002 mol%, whereas the homogeneous counterpart affords almost no conversion of epoxide under similar reaction conditions. the high activity of the solid nanoreactor is mainly attributed to the greatly intensified cooperative activation in the nanocages as evidenced by the sharply increased tof in parallel with cr(salen) concentration in each nanocage. the increased nucleophilicity of cr(salen) after coordination to pyridine could also promote the catalytic activity. the solid nanoreactor can be easily separated and recycled. we demonstrated the possibility for designing an efficient solid nanoreactor for asymmetric catalysis by taking the advantages of the cooperative activation.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	ring-opening reactions ; salen complexes ; asymmetric catalysis ; mesoporous silica ; metal-complexes ; cr-iii(salen) ; impregnation ; cage
收录类别	SCI
语种	英语
WOS记录号	WOS:000306931300029
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117933]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bai, Shiyang,Li, Bo,Peng, Juan,et al. Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides[J]. chemical science,2012,3(9):2864-2867.
APA	Bai, Shiyang,Li, Bo,Peng, Juan,Zhang, Xiaoming,Yang, Qihua,&Li, Can.(2012).Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides.chemical science,3(9),2864-2867.
MLA	Bai, Shiyang,et al."Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides".chemical science 3.9(2012):2864-2867.