Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes

doi:10.1021/acsbiomaterials.0c00340

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes
	Shen, ZW ; Guo, Z ; Tan, TY ; Hu, J ; Zhang, Y
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2020
卷号	6 期号:7 页码:3957-3966
关键词	OXIDATIVE STRESS DAMAGE STEM-CELLS SUPPRESSION THERAPY ALPHA
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.0c00340
文献子类	期刊论文
英文摘要	Myocardial ischemia-reperfusion produces a large amount of reactive oxygen species (ROS), which damage the myocardial tissue. Therefore, localized scavenging of ROS from the myocardial tissue would reduce its damage and avoid metabolic abnormalities caused by systemic ROS. In this study, a free radical scavenging and biodegradable supramolecular peptide (ECAFF, named as ECF-5) hydrogel was designed as a culture scaffold for cardiomyocytes. The peptide hydrogel significantly preserved the migration and proliferation of cardiomyocytes and reduced their damage from oxidative stress. In addition, the hydrogel degraded during cell growth, which implies that it may avoid thrombosis of the capillaries in practical use and provide the opportunity for the cells to attach to each other and form a functional tissue. The hydrogel can be used as a 3D culture scaffold for cardiomyocyte culture and allow cardiomyocytes to grow into tissue-like cell spheres. The excellent nature of the ECF-5 hydrogel enables it to have broad applications in the biomedical field in the future.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33105]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Shen, ZW,Guo, Z,Tan, TY,et al. Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(7):3957-3966.
APA	Shen, ZW,Guo, Z,Tan, TY,Hu, J,&Zhang, Y.(2020).Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(7),3957-3966.
MLA	Shen, ZW,et al."Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.7(2020):3957-3966.