In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts

doi:10.1080/17435390.2020.1860264

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts
	Cao, MJ ; Li, B ; Guo, MY ; Liu, Y ; Zhang, LL ; Wang, YL ; Hu, B ; Li, JY ; Sutherland, DS ; Wang, LM
刊名	NANOTOXICOLOGY
页码	-
ISSN号	1743-5390
DOI	10.1080/17435390.2020.1860264
文献子类	期刊论文
英文摘要	The increasing emergence of nano-cosmetics in the marketplace provokes safety concerns with respect to percutaneous permeation and toxicity of nanomaterials inside the human body. In this study, in vivo percutaneous permeation and dermal safety of cosmetic cream containing Au nanosheets and extracted Au nanosheets from cosmetic creams are investigated with guinea pigs. Quantitative percutaneous permeation data suggests that Au nanosheets in cosmetic creams permeate into the skin epidermis, dermis, and subcutaneous layer after 10 d cutaneous exposure, but cannot enter the systemic circulation. However, more Au nanosheets are accumulated in the skin and the permeation of Au nanosheets increased after embedded into the cream matrix. Synchrotron radiation X-ray fluorescence (SRXRF) imaging reveals that Au nanosheets in cosmetics penetrate mainly through hair follicles in a time-dependent manner. Cosmetic creams rather than extracted Au nanosheets decrease the cell viability of keratinocytes and slightly induce apoptosis/necrosis of keratinocytes and skin dermal fibroblasts. Intriguingly, the growth of hair is inhibited by the cosmetic cream and the extracted Au nanosheets revealed by HE staining and immunohistochemistry (IHC) assay. Altogether this study provides insights into the comprehensive understanding of percutaneous permeation and dermal safety of cosmetic creams containing Au nanosheets. This work provides reliable methods to study the skin permeation, biodistribution, and dermal safety of nano-cosmetics and reminds the community of the crucial need to combine the assays at molecular, cellular, and organ levels in nanotoxicology research.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32933]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Aarhus Univ, iNANO Interdisciplinary Nanosci Ctr, Aarhus, Denmark 2.Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11,1st Northern St, Beijing 100190, Peoples R China 5.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, 11,1st Northern St, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Sino Danish Coll, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cao, MJ,Li, B,Guo, MY,et al. In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts[J]. NANOTOXICOLOGY:-.
APA	Cao, MJ.,Li, B.,Guo, MY.,Liu, Y.,Zhang, LL.,...&Chen, CY.
MLA	Cao, MJ,et al."In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts".NANOTOXICOLOGY