Broadband terahertz signatures and vibrations of dopamine

doi:10.1039/d0an00771d

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Broadband terahertz signatures and vibrations of dopamine
	Zhu, ZJ ; Zhang, JB ; Song, YS ; Chang, C ; Ren, GH ; Shen, JX ; Zhang, ZC ; Ji, T ; Chen, M ; Zhao, HW
刊名	ANALYST
	2020
卷号	145 期号:18 页码:6006-6013
关键词	GAS-PHASE INFRARED-SPECTROSCOPY RECEPTOR SPECTRA NEUROTRANSMITTERS CONFORMATION MODES
ISSN号	0003-2654
DOI	10.1039/d0an00771d
文献子类	期刊论文
英文摘要	Dopamine (DA) is an essential neurotransmitter and hormone of the nervous system, its structural and conformational properties play critical roles in biological functions and signal transmission processes. Although this neuroactive molecule has been studied extensively, the low-frequency vibration features that are closely related to the conformation and molecular interactions in the terahertz (THz) band still remain unclear. In this study, a broadband THz time-domain spectroscopy (THz-TDS) system in the frequency band of 0.5-18 THz was used to characterize the unique THz fingerprint of DA. In addition, density functional theory (DFT) calculations were performed to analyze the vibrational properties of DA. The results suggest that each THz resonant absorption peak of DA corresponds to specific vibrational modes, and the collective vibration also exists in the broadband THz range. Moreover, the interactions between the DA ligand and the D2 and D3 receptors were investigated by docking, and the simulated THz spectra were obtained. The results indicate the dominant role of hydrogen bonding interactions and the specificity of molecular conformation. This work may help to understand the resonance coupling between THz electromagnetic waves and neurotransmitters.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32735]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China 3.Natl Innovat Inst Def Technol, Innovat Lab Terahertz Biophys, Beijing 100071, Peoples R China 4.East China Univ Sci & Technol, Shanghai 200237, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, ZJ,Zhang, JB,Song, YS,et al. Broadband terahertz signatures and vibrations of dopamine[J]. ANALYST,2020,145(18):6006-6013.
APA	Zhu, ZJ.,Zhang, JB.,Song, YS.,Chang, C.,Ren, GH.,...&Zhao, HW.(2020).Broadband terahertz signatures and vibrations of dopamine.ANALYST,145(18),6006-6013.
MLA	Zhu, ZJ,et al."Broadband terahertz signatures and vibrations of dopamine".ANALYST 145.18(2020):6006-6013.