The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism | |
Jia, Haiying5; He, Mingwei3; Zhang, Xiaoyue2,4; Li, Yuling2,4; He, Shu-chang2,4; Zhang, Xiang-Yang1 | |
刊名 | PSYCHOPHARMACOLOGY |
2021-07-10 | |
通讯作者邮箱 | shuchangh@pku.edu.cn (shu‑chang he ) ; zhangxy@psych.ac.cn (xiang‑yang zhang ) |
页码 | 9 |
关键词 | Job stress Job burnout Brain-derived neurotrophic factor (BDNF) Gene-environment interaction |
ISSN号 | 0033-3158 |
DOI | 10.1007/s00213-021-05911-x |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | Rationale Job stress can lead to job burnout, and BDNF polymorphism has been found to be involved in its psychopathological mechanism. Research needs a better understanding of the important role of gene x environment (i.e., BDNF polymorphism x job stress) interaction on job burnout. Objective This study aimed to explore how BDNF rs6265 polymorphism may moderate the relationship between job stress and job burnout. Methods Three hundred forty-one healthy participants (187 males and 154 females) from a Chinese university were included. The present study used a standardized questionnaire including demographic characteristics, job stress assessed by the House and Rizzo's Work Stress Scale, and job burnout assessed by the Maslach Burnout Inventory-General Survey. The BDNF rs6265 polymorphism was genotyped. Results Job stress showed a positive correlation with emotional exhaustion (p < 0.001), cynicism (p < 0.001), and reduced personal accomplishment (p < 0.01). The main effects of BDNF rs6265 polymorphism on emotional exhaustion and cynicism were significant [F-(1,F-333) = 5.136, p = 0.024; F-(1,F-333) = 4.175, p = 0.042, respectively]. The interaction between job stress and BDNF rs6265 on cynicism was significant (o R-2 = 0.013, p = 0.014) after controlling for age, sex, education, and position, indicating that individuals with BDNF rs6265 TT genotype showed higher level of cynicism when in high job stress. Conclusions The results provided evidence for the association of BDNF gene rs6265 polymorphism, job stress, and their interaction with job burnout. Individuals with TT genotype in BDNF rs6265 might be susceptible to stressful situations, which would lead to cynicism. |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81871060] |
WOS关键词 | FACTOR VAL66MET POLYMORPHISM ; NEUROTROPHIC FACTOR ; SERUM BDNF ; DEPRESSIVE SYMPTOMS ; SCHOOL TEACHERS ; BRAIN ; SUSCEPTIBILITY ; HEALTH ; CONFLICT ; MEMORY |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
语种 | 英语 |
出版者 | SPRINGER |
WOS记录号 | WOS:000672437900001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/39827] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | He, Shu-chang; Zhang, Xiang-Yang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 3.Capital Med Univ, Beijing Anzhen Hosp, 2 Anzhen Rd, Beijing 100029, Peoples R China 4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 5.PLA Strateg Support Force Characterist Med Ctr, Special Serv Personnel Hlth Management Dept, 9 Anxiang Beili, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,et al. The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism[J]. PSYCHOPHARMACOLOGY,2021:9. |
APA | Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,Li, Yuling,He, Shu-chang,&Zhang, Xiang-Yang.(2021).The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism.PSYCHOPHARMACOLOGY,9. |
MLA | Jia, Haiying,et al."The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism".PSYCHOPHARMACOLOGY (2021):9. |
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