Cognitive training modified age-related brain changes in older adults with subjective memory decline

doi:10.1080/13607863.2021.1972931

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Cognitive training modified age-related brain changes in older adults with subjective memory decline
	Yin, Shufei 2,3; Xiong, Jinli 2; Zhu, Xinyi 1,3; Li, Rui 3; Li, Juan 1,3
刊名	AGING & MENTAL HEALTH
	2021-08-26
页码	9
关键词	brain plasticity cognitive training older adults subjective memory decline resting-state fMRI
ISSN号	1360-7863
DOI	10.1080/13607863.2021.1972931
通讯作者	Yin, Shufei(yinshufei121@163.com) ; Li, Juan(lijuan@psych.ac.cn)
英文摘要	Objectives Neuroimaging findings suggest that older adults with subjective memory decline (SMD) demonstrate some neurodegenerative brain changes and have high risk of developing dementia, but relatively little is known about the effectiveness of interventions for SMD. This study aimed to examine the effects of cognitive training on resting-state brain activity in SMD. Method This study employed the amplitude of low frequency fluctuations (ALFF) and resting state functional connectivity (rs-FC) analyses. After baseline evaluations, participants were randomly allocated to the intervention and control group to receive a four-week cognitive training and lectures on health and aging, respectively. All participants were scanned before and after training with an interval of about three months. Results (1) Participants in the intervention group showed significant improvements on the Associative Learning Test (ALT) and the Digit Span Forward task compared to the control group; (2) ALFF in the occipital lobe for the control group increased significantly, while that for the intervention group remained the same; ALFF changes were negatively correlated with ALT performance in the control group; (3) The mean value of rs-FC for the intervention group decreased, while that for the control group showed a trend of increase; rs-FC changes were also negatively correlated with ALT performance in the control group. Conclusions Resting-state brain activities in occipital region increased with aging. The cognitive training could counteract this brain function changes associated with aging or even reverse the changes. These findings provide new insights into the understanding of brain plasticity in posterior areas in SMD.
收录类别	SCI
资助项目	National Key Research and Development Program of China[2018YFC2000300] ; National Key Research and Development Program of China[2018YFC2001701] ; National Key Research and Development Program of China[2020YFC2003000] ; National Key Research and Development Program of China[2016YFC1305900] ; National Key Research and Development Program of China[2017YFB1401203] ; National Natural Science Foundation of China[31600904] ; National Natural Science Foundation of China[32071079] ; National Natural Science Foundation of China[31861133011] ; National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[61673374] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2020K03] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX191005]
WOS关键词	FUNCTIONAL CONNECTIVITY ; PEOPLE ; RISK ; MCI ; AD ; ASSOCIATION ; IMPROVEMENT ; IMPAIRMENT ; ACTIVATION ; PLASTICITY
WOS研究方向	Geriatrics & Gerontology ; Psychiatry
语种	英语
出版者	ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
WOS记录号	WOS:000694613200001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40192]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Yin, Shufei; Li, Juan
作者单位	1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Hubei Univ, Fac Educ, Dept Psychol, Wuhan, Peoples R China 3.Chinese Acad Sci, Ctr Aging Psychol, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yin, Shufei,Xiong, Jinli,Zhu, Xinyi,et al. Cognitive training modified age-related brain changes in older adults with subjective memory decline[J]. AGING & MENTAL HEALTH,2021:9.
APA	Yin, Shufei,Xiong, Jinli,Zhu, Xinyi,Li, Rui,&Li, Juan.(2021).Cognitive training modified age-related brain changes in older adults with subjective memory decline.AGING & MENTAL HEALTH,9.
MLA	Yin, Shufei,et al."Cognitive training modified age-related brain changes in older adults with subjective memory decline".AGING & MENTAL HEALTH (2021):9.