Biological correlates before esophageal cancer screening and after diagnosis

doi:10.1038/s41598-021-96548-5

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Biological correlates before esophageal cancer screening and after diagnosis
	Zhu, Juan 2; Ma, Shanrui 2; Chen, Ru 2; Xie, Shuanghua 2; Liu, Zhengkui 1; Li, Xinqing 2; Wei, Wenqiang 2
刊名	SCIENTIFIC REPORTS
	2021-08-23
卷号	11 期号:1 页码:8
ISSN号	2045-2322
DOI	10.1038/s41598-021-96548-5
通讯作者	Wei, Wenqiang(weiwq@cicams.ac.cn)
英文摘要	Almost 50% of the world's esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Box-Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. The median of cortisol, IgA, IgG, and IgM in pre-screening was 15.46 ug/dL, 1.86 g/L, 12.14 g/L, and 0.91 g/L, corresponding value at post-diagnosis was 15.30 ug/dL, 2.00 g/L, 12.79 g/L, and 0.94 g/L, respectively. No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. After normality transformation, cortisol, IgA, IgG and IgM levels were (0.25 +/- 0.04) U/mL, (0.72 +/- 0.13) (g/L), (2.44 +/- 0.22) (g/L) and (0.98 +/- 0.25) (g/L) before screening, (0.25 +/- 0.05) U/mL, (0.70 +/- 0.13) (g/L), (2.48 +/- 0.21) (g/L) and (1.00 +/- 0.25) (g/L) after diagnosis, respectively. Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis (P = 0.019). No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). Little biological correlates were found both before screening and after diagnosis. Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. Further multi-round longitudinal studies are needed to validate these results.
收录类别	SCI
资助项目	National Key Research and Development Program (Precision Medicine Research)[2016YFC0901400] ; National Key Research and Development Program (Precision Medicine Research)[2016YFC0901404]
WOS关键词	NEUROENDOCRINE RESPONSES ; PSYCHOLOGICAL STRESS ; AXIS DYSREGULATION ; FOLLOW-UP ; HPA AXIS ; CORTISOL ; ANXIETY ; DEPRESSION ; CHINA ; VULNERABILITY
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000687795500037
资助机构	National Key Research and Development Program (Precision Medicine Research)
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40118]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Wei, Wenqiang
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Natl Canc Registry Off,Canc Hosp, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Juan,Ma, Shanrui,Chen, Ru,et al. Biological correlates before esophageal cancer screening and after diagnosis[J]. SCIENTIFIC REPORTS,2021,11(1):8.
APA	Zhu, Juan.,Ma, Shanrui.,Chen, Ru.,Xie, Shuanghua.,Liu, Zhengkui.,...&Wei, Wenqiang.(2021).Biological correlates before esophageal cancer screening and after diagnosis.SCIENTIFIC REPORTS,11(1),8.
MLA	Zhu, Juan,et al."Biological correlates before esophageal cancer screening and after diagnosis".SCIENTIFIC REPORTS 11.1(2021):8.