Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells

doi:10.1021/acs.organomet.7b00897

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	Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells
	Gong, Guidong 2; Cao, Yuan 2; Wang, Fei 1; Zhao, Gang 2
刊名	ORGANOMETALLICS
	2018
卷号	37 期号:7 页码:1103-1113
ISSN号	0276-7333
DOI	10.1021/acs.organomet.7b00897
产权排序	2
文献子类	Article
英文摘要	A series of planar chiral ferrocene cydopalladated compounds were synthesized and characterized. The absolute configurations of four compounds were determined by single-crystal X-ray analysis. The cytotoxic activities of the synthesized compounds and cisplatin exhibited different inhibition potencies on the viability of human liver, breast, and colon cancer cell lines. The dinuclear compound 7 was 16-fold more potent than cisplatin in hepatoma cells. Compound 7 was also more effective than cisplatin in the inhibition of hepatoma cell metastasis. Flow cytometry analysis and caspase activity assays indicated that compound 7 exerted antiproliferative activity in cancer cells through the induction of caspase-dependent apoptosis.
学科主题	Organic Chemistry ; Polymer Science
URL标识	查看原文
WOS关键词	BENZOPHENONE IMINES SYNTHESIS ; CYTOCHROME-C RELEASE ; CATHEPSIN-B ACTIVITY ; ANTITUMOR-ACTIVITY ; DNA INTERACTION ; BRIDGED DIMERS ; LEUKEMIA-CELLS ; COMPLEXES ; PERMEABILIZATION ; CYTOTOXICITY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000429886300003
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30733]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu 610041, Sichuan, Peoples R China 2.Sichuan Univ, Coll Chem Engn, Chengdu 610064, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Gong, Guidong,Cao, Yuan,Wang, Fei,et al. Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells[J]. ORGANOMETALLICS,2018,37(7):1103-1113.
APA	Gong, Guidong,Cao, Yuan,Wang, Fei,&Zhao, Gang.(2018).Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells.ORGANOMETALLICS,37(7),1103-1113.
MLA	Gong, Guidong,et al."Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells".ORGANOMETALLICS 37.7(2018):1103-1113.