Determination of organic acids for quality evaluation in Coptis herbs by ion chromatography

doi:10.1007/s13205-018-1300-5

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	Determination of organic acids for quality evaluation in Coptis herbs by ion chromatography
	Li, Dongmei 3; Zhou, Lili 2; Wang, Qingwei 1; He, Yang 3
刊名	3 BIOTECH
	2018
卷号	8 期号:6 页码:285
关键词	Coptis herbs Organic acids Ion chromatography Herbal quality
ISSN号	2190-572X
DOI	10.1007/s13205-018-1300-5
产权排序	3
文献子类	Article
英文摘要	Coptis herbs are important herbal medicinal materials. The bioactive composition, the quality and medicinal efficacy of these herbs, are determined significantly by their geo-authentic features. Among the effective components of these herbs are seven organic acids (quinic, acetic, formic, tartaric, malic, succinic, and oxalic acids). However, no quantitative data of these seven acids in these herbs are available. Therefore, we developed a method for simultaneous separation and determination of the seven organic acids in Coptis herbs using gradient ion chromatography (mobile phase and gradient were shown in Table 1). The seven acids were separated and determined in no more than 35 min. We found that the organic acid levels in C. teeta was obviously higher than in C. chinensis and C. deltoidea, in particular, the content of quinic acid in C. teeta was about eight times than that in C. chinensis and C. deltoidea. Furthermore, we analyzed the relationships between the contents of organic acids and clinical effects, and found that organic acids (content of total acids or content of quinic acid) could act as an reference ingredient for quality evaluation in Coptis herbs. Our studies would lay the foundation for effective quality evaluation of these herbs.
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WOS关键词	ALKALOIDS ; RATS
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000434009200001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30700]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China 2.Inst Measurement & Testing Technol, Chengdu 610021, Sichuan, Peoples R China; 3.Chengdu Univ Tradit Chinese Med, Coll Med Technol, Chengdu 611137, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Li, Dongmei,Zhou, Lili,Wang, Qingwei,et al. Determination of organic acids for quality evaluation in Coptis herbs by ion chromatography[J]. 3 BIOTECH,2018,8(6):285.
APA	Li, Dongmei,Zhou, Lili,Wang, Qingwei,&He, Yang.(2018).Determination of organic acids for quality evaluation in Coptis herbs by ion chromatography.3 BIOTECH,8(6),285.
MLA	Li, Dongmei,et al."Determination of organic acids for quality evaluation in Coptis herbs by ion chromatography".3 BIOTECH 8.6(2018):285.