Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo

doi:10.1021/acsami.8b19658

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	Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo
	Yang, Xinglong 5; Wei, Qin 5; Shao, Huawu 3,4; Jiang, Xingyu 1,2,3,5
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019
卷号	11 期号:8 页码:7725-7730
关键词	aminosaccharide gold nanoparticles multidrug-resistant bacteria antibacterial activity biofilm
ISSN号	1944-8244
DOI	10.1021/acsami.8b19658
产权排序	2
文献子类	Article
英文摘要	Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using D-glucosamine (G1uN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
学科主题	Applied Physics/condensed Matter/materials Science
URL标识	查看原文
WOS关键词	BACTERIAL BIOFILMS ; SMALL MOLECULES ; RESISTANCE ; COMPLEX
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000460365300010
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30536]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China 2.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China; 5.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Xinglong,Wei, Qin,Shao, Huawu,et al. Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(8):7725-7730.
APA	Yang, Xinglong,Wei, Qin,Shao, Huawu,&Jiang, Xingyu.(2019).Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo.ACS APPLIED MATERIALS & INTERFACES,11(8),7725-7730.
MLA	Yang, Xinglong,et al."Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo".ACS APPLIED MATERIALS & INTERFACES 11.8(2019):7725-7730.