D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria

doi:10.7150/thno.22540

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	D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria
	Yang, Xinglong 1,3,4,5; Dang, Yan 2; Lou, Jinli 2; Shao, Huawu 4; Jiang, Xingyu 3,5
刊名	THERANOSTICS
	2018
卷号	8 期号:5 页码:1449-1457
关键词	gold nanoparticles D-amino acid bacteria spontaneous bacterial peritonitis colorimetric biosensor
ISSN号	1838-7640
DOI	10.7150/thno.22540
产权排序	2
文献子类	Article
英文摘要	Rationale: Rapid and facile detection of pathogenic bacteria is challenging due to the requirement of large-scale instruments and equipment in conventional methods. We utilize D-amino acid as molecules to selectively target bacteria because bacteria can incorporate DADA in its cell wall while mammalian cells or fungi cannot. Methods: We show a broad-spectrum bacterial detection system based on D-amino acid-capped gold nanoparticles (AuNPs). AuNPs serve as the signal output that we can monitor without relying on any complex instruments. Results: In the presence of bacteria, the AuNPs aggregate and the color of AuNPs changes from red to blue. This convenient color change can distinguish between Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). This system can be applied for detection of ascites samples from patients. Conclusion: These D-amino acid-modified AuNPs serve as a promising platform for rapid visual identification of pathogens in the clinic.
URL标识	查看原文
WOS关键词	D-AMINO ACIDS ; MULTIDRUG-RESISTANT BACTERIA ; CELL-WALL ; PEPTIDOGLYCAN BIOSYNTHESIS ; SILVER NANOPARTICLES ; PHOTOTHERMAL THERAPY ; MEDIATED GROWTH ; SMALL MOLECULES ; NAKED EYE ; CANCER
WOS研究方向	Research & Experimental Medicine
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000424515900020
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30371]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China 2.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, 8 Youan Men Wai Xi TouTiao, Beijing 100069, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China; 5.ZhongGuanCun BeiYiTiao, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Natl Ctr NanoSci & Technol,CAS Ctr Excellence Nan, Beijing 100190, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Xinglong,Dang, Yan,Lou, Jinli,et al. D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria[J]. THERANOSTICS,2018,8(5):1449-1457.
APA	Yang, Xinglong,Dang, Yan,Lou, Jinli,Shao, Huawu,&Jiang, Xingyu.(2018).D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria.THERANOSTICS,8(5),1449-1457.
MLA	Yang, Xinglong,et al."D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria".THERANOSTICS 8.5(2018):1449-1457.