The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration

doi:10.1002/jcp.26169

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	The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration
	Han, Xiaojuan 2; Chen, Honghan 2; Zhou, Jiao 2; Tai, Haoran 2; Gong, Hui 2; Wang, Xiaobo 2; Huang, Ning 2; Qin, Jianqiong 2; Fang, Tingting 2; Wang, Fei 1
刊名	JOURNAL OF CELLULAR PHYSIOLOGY
	2018-05-01
卷号	233 期号:5 页码:3945-3954
关键词	AMPK autophagy fraxinellone oxidative stress senescence
ISSN号	0021-9541
DOI	10.1002/jcp.26169
产权排序	2
文献子类	Article
英文摘要	As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti-inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence-induced by oxidative stress and the potential mechanism. We found that fraxinellone administration caused growth arrest and certainly repressed the activity of senescence associated -galactosidase as well as the expression of senescence-associated-genes. Interestingly, this effect of fraxinellone is closely correlated with the restoration of impaired autophagy and the activation of AMPK. Notably, fraxinellone reacts in an AMPK-dependent but mTORC1-independent manner. Together, our study demonstrates for the first time that fraxinellone has the effect on senescence inhibition and AMPK activation, and supports the notion that autophagic mechanism is important for aging prevention. These findings expanded the list of natural compounds and will be potentially utilized for aging decay and/or AMPK activation.
学科主题	Cell ; Developmental Biology
URL标识	查看原文
WOS关键词	DICTAMNUS-DASYCARPUS ; LIFE-SPAN ; CALORIC RESTRICTION ; SIGNALING PATHWAY ; ROOT BARK ; DISEASE ; PHOSPHORYLATION ; BIOSYNTHESIS ; MACROPHAGES ; METABOLISM
WOS研究方向	Cell Biology ; Physiology
语种	英语
出版者	WILEY
WOS记录号	WOS:000424644700021
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30269]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China 2.Lab for Aging Research, Center of Gerontology and Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China;
推荐引用方式 GB/T 7714	Han, Xiaojuan,Chen, Honghan,Zhou, Jiao,et al. The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2018,233(5):3945-3954.
APA	Han, Xiaojuan.,Chen, Honghan.,Zhou, Jiao.,Tai, Haoran.,Gong, Hui.,...&Xiao, Hengyi.(2018).The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration.JOURNAL OF CELLULAR PHYSIOLOGY,233(5),3945-3954.
MLA	Han, Xiaojuan,et al."The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration".JOURNAL OF CELLULAR PHYSIOLOGY 233.5(2018):3945-3954.