Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats

doi:10.1515/chem-2018-0021

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 生物多样性与生态系统服务领域 > 中国科学院山地生态恢复与生物资源利用重点实验室

	Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats
	Ullah, Riaz 1,7; Alsaid, Mansour S.1; Shahat, Abdelaaty A.1,2; Naser, Almoqbil Abdulaziz 1; Al-Mishari, Abdullah A.1; Adnan, Muhammad 3; Tariq, Akash 5,6
刊名	OPEN CHEMISTRY
	2018
卷号	16 期号:1 页码:133-140
关键词	Z. spinosa H. elegans hepatoprotective
ISSN号	2391-5420
DOI	10.1515/chem-2018-0021
产权排序	5
文献子类	Article
英文摘要	The detoxification, metabolism, and excretion of various endogenous and exogenous materials occur mainly in the liver. Liver diseases are a global concern, and classified as chronic hepatitis, cirrhosis, and hepatosis. The development of safe hepatoprotective agents remains an unmet need. Therefore, we investigated the antioxidant effects of methanolic and n-hexane fractions of Zilla spinosa (ZSM and ZSH, respectively) and Hammada elegans (HEM and HEH, respectively) against carbon tetrachloride (CCl4)-induced liver toxicity in rats. Antioxidant activity was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The rats were divided into 11 groups (n=6)-group 1 (control), group 2 (CCl4 only), group 3 (CCl4 + silymarin 10 mg/kg), group 4 (CCl4 + HEM 250 mg/kg), group 5 (CCl4 + HEM 500 mg/kg), group 6 (CCl4 + HEH 250 mg/kg), group 7 (CCl4 + HEH 500 mg/kg), group 8 (CCl4 + ZSM 250 mg/kg),
学科主题	Chemistry
URL标识	查看原文
WOS关键词	LIVER ; DISEASE
WOS研究方向	Chemistry
语种	英语
出版者	DE GRUYTER POLAND SP ZOO
WOS记录号	WOS:000427650900010
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30383]
专题	生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
作者单位	1.Department of Pharmacognosy and Medicinal, Aromatic & Poisonous Plants Research Center MAPPRC),College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; 2.Res Ctr, Phytochem Dept, 33 El Bohouth St,POB12622, Giza, Egypt; 3.Kohat Univ Sci & Technol KUST KPK Pakistan, Dept Bot, Kohat, Pakistan; 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Chengdu Inst Biol, Ecol Restorat Biodivers Conservat Key Lab Sichuan, Chengdu 610041, Sichuan, Peoples R China; 6.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat f, Chengdu 610041, Sichuan, Peoples R China; 7.Govt Coll Ara Khel FR Kohat KPK Pakistan, Dept Chem, Kohat, Pakistan;
推荐引用方式 GB/T 7714	Ullah, Riaz,Alsaid, Mansour S.,Shahat, Abdelaaty A.,et al. Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats[J]. OPEN CHEMISTRY,2018,16(1):133-140.
APA	Ullah, Riaz.,Alsaid, Mansour S..,Shahat, Abdelaaty A..,Naser, Almoqbil Abdulaziz.,Al-Mishari, Abdullah A..,...&Tariq, Akash.(2018).Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats.OPEN CHEMISTRY,16(1),133-140.
MLA	Ullah, Riaz,et al."Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachloride-induced Hepatotoxicity in Rats".OPEN CHEMISTRY 16.1(2018):133-140.