Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica

doi:10.1016/j.phytochem.2018.01.018

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	Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica
	Zhao, Min 2; Yuan, Lv-Yi 3; Guo, Da-Le 4; Ye, Ye 2; Da-Wa, Zhuo-Ma 1; Wang, Xiao-Ling 3; Ma, Feng-Wei 2; Chen, Lei 2; Gu, Yu-Cheng 5; Ding, Li-Sheng 2
刊名	PHYTOCHEMISTRY
	2018-04-01
卷号	148 期号:2018 页码:97-103
关键词	Przewalskia tangutica Solanaceae Lachnum palmae Hyaloscyphaceae Chemical epigenetic manipulation Dihydroisocoumarins
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2018.01.018
产权排序	1
文献子类	Article
英文摘要	Guided by the UPLC-ESIMS profile, seven previously undescribed halogenated dihydroisocoumarins, palmaerones A-G, along with eleven known dihydroisocoumarins, were isolated from Lachnum palmae, an endophytic fungus from Przewalskia tangutica by exposure to a histone deacetylase inhibitor SAHA. Structures of the isolates were elucidated by analysis of their NMR, MS and optical rotation values. The antimicrobial, anti-inflammatory and cytotoxic activities of palmaerones A-G were evaluated. Palmaerones A-G showed antimicrobial activities against the strains (C. neoformans, Penicillium sp., C. albicans, B. subtilis and S. aureus), and palmaerone E exhibited potential antimicrobial activities against all the test strains with the MIC value in the range of 10-55 mu g/mL. Palmaerones A and E exhibited moderate inhibitory effects on NO production in LPS-induced RAW 264.7 cells, with the IC50 values of 26.3 and 38.7 mu M, respectively and no obvious toxicities were observed at 50 mu M. Palmaerone E showed weak cytotoxicity against HepG2 with the IC50 value of 42.8 mu M. This work provides an effective strategy for expanding natural product resource. (C) 2018 Elsevier Ltd. All rights reserved.
学科主题	Agricultural Chemistry
URL标识	查看原文
WOS关键词	HISTONE DEACETYLASE INHIBITOR ; SUBEROYLANILIDE HYDROXAMIC ACID ; ENTOMOPATHOGENIC FUNGUS ; CORDYCEPS-INDIGOTICA ; CIRCULAR-DICHROISM ; ASPERGILLUS-NIGER ; POLYKETIDE ; METABOLITES
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000427334600012
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30293]
专题	生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
作者单位	1.Tibet Autonomous Reg Inst Food & Drug Control, Lhasa 850000, Peoples R China; 2.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Sichuan, Peoples R China; 3.Southwest Univ Nationalities, Chengdu 610041, Sichuan, Peoples R China; 4.Chengdu Univ TCM, Chengdu 610041, Sichuan, Peoples R China; 5.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
推荐引用方式 GB/T 7714	Zhao, Min,Yuan, Lv-Yi,Guo, Da-Le,et al. Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica[J]. PHYTOCHEMISTRY,2018,148(2018):97-103.
APA	Zhao, Min.,Yuan, Lv-Yi.,Guo, Da-Le.,Ye, Ye.,Da-Wa, Zhuo-Ma.,...&Zhou, Yan.(2018).Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica.PHYTOCHEMISTRY,148(2018),97-103.
MLA	Zhao, Min,et al."Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica".PHYTOCHEMISTRY 148.2018(2018):97-103.