Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization

doi:10.3389/fmicb.2018.01745

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 食品安全与环境治理领域 > 应用与环境微生物研究

	Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization
	Li, Huan 6; Li, Tongtong 5; Li, Xiangzhen 4; Wang, Guanhong 3; Lin, Qiang 2; Qu, Jiapeng 1,7
刊名	FRONTIERS IN MICROBIOLOGY
	2018
卷号	9 页码:1745
关键词	gut microbiota urbanization beta diversity network interaction environmental filtering lifestyle
ISSN号	1664-302X
DOI	10.3389/fmicb.2018.01745
产权排序	3
文献子类	Article
英文摘要	Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray-Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g , low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes.
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WOS关键词	ECOLOGICAL PROCESSES ; ASSEMBLY PROCESSES ; NEUTRAL THEORY ; DIVERSITY ; COMMUNITIES ; PATTERNS ; SUCCESSION ; GRADIENTS ; SEQUENCES ; ECOSYSTEM
WOS研究方向	Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000440311400001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30675]
专题	环境治理与食品安全领域_应用与环境微生物研究
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China; 2.Czech Acad Sci, Inst Soil Biol, Ceske Budejovice, Czech Republic; 3.Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA; 4.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 5.Zhejiang Univ Technol, Dept Appl Biol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China; 6.Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China; 7.Qinghai Prov Key Lab Restorat Ecol Cold Reg, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Huan,Li, Tongtong,Li, Xiangzhen,et al. Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization[J]. FRONTIERS IN MICROBIOLOGY,2018,9:1745.
APA	Li, Huan,Li, Tongtong,Li, Xiangzhen,Wang, Guanhong,Lin, Qiang,&Qu, Jiapeng.(2018).Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.FRONTIERS IN MICROBIOLOGY,9,1745.
MLA	Li, Huan,et al."Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization".FRONTIERS IN MICROBIOLOGY 9(2018):1745.