Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization | |
Li, Huan6; Li, Tongtong5; Li, Xiangzhen4; Wang, Guanhong3; Lin, Qiang2; Qu, Jiapeng1,7 | |
刊名 | FRONTIERS IN MICROBIOLOGY
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2018 | |
卷号 | 9页码:1745 |
关键词 | gut microbiota urbanization beta diversity network interaction environmental filtering lifestyle |
ISSN号 | 1664-302X |
DOI | 10.3389/fmicb.2018.01745 |
产权排序 | 3 |
文献子类 | Article |
英文摘要 | Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray-Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g , low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes. |
URL标识 | 查看原文 |
WOS关键词 | ECOLOGICAL PROCESSES ; ASSEMBLY PROCESSES ; NEUTRAL THEORY ; DIVERSITY ; COMMUNITIES ; PATTERNS ; SUCCESSION ; GRADIENTS ; SEQUENCES ; ECOSYSTEM |
WOS研究方向 | Microbiology |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000440311400001 |
内容类型 | 期刊论文 |
源URL | [http://210.75.237.14/handle/351003/30675] ![]() |
专题 | 环境治理与食品安全领域_应用与环境微生物研究 |
作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China; 2.Czech Acad Sci, Inst Soil Biol, Ceske Budejovice, Czech Republic; 3.Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA; 4.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 5.Zhejiang Univ Technol, Dept Appl Biol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China; 6.Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China; 7.Qinghai Prov Key Lab Restorat Ecol Cold Reg, Xining, Qinghai, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Huan,Li, Tongtong,Li, Xiangzhen,et al. Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization[J]. FRONTIERS IN MICROBIOLOGY,2018,9:1745. |
APA | Li, Huan,Li, Tongtong,Li, Xiangzhen,Wang, Guanhong,Lin, Qiang,&Qu, Jiapeng.(2018).Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.FRONTIERS IN MICROBIOLOGY,9,1745. |
MLA | Li, Huan,et al."Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization".FRONTIERS IN MICROBIOLOGY 9(2018):1745. |
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