Investigation of peptoid chiral stationary phases varied in absolute configuration

	Investigation of peptoid chiral stationary phases varied in absolute configuration
	Wu, Haibo 1; Li, Kuiyong 1; Yu, Hui 1; Ke, Yanxiong 1; Liang, Xinmiao 1,2
刊名	journal of chromatography a
	2013-03-15
卷号	1281 页码:155-159
关键词	Peptoid Oligopeptoid Diastereoisomeric selectors Chiral stationary phase
通讯作者	柯燕雄 ; 梁鑫淼
产权排序	2,5
英文摘要	based on chiral n-(1-phenylethyl) glycines, a series of peptoid chiral stationary phases (csps) terminated with achiral alkyl group (diisopropyl, t-butyl or n-butyl) and varied in absolute configuration of selector were investigated with nine axially chiral analytes. it is very interesting to observe that selectors with heterogeneous configuration form, such as s-r-r, s-r-s, s-s-r, generally performed better than s-s-s selectors. moreover, longer s-r-s-r-s selector did not outperform the s-r-s one obviously, with several separations declined. in addition to the result that the elution order of most enantiomers depends on the asymmetric center adjacent to the terminus of selector, we presume that the moieties around this chiral center are the most important absorbing sites for chiral discrimination; the terminal group and other chiral blocks in selector may assist enantiorecognition by constructing appropriate conformation. various terminal alkyl groups also resulted in a few differences in enantioselectivity. (c) 2013 published by elsevier b.v.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	performance liquid-chromatography ; varying peptide length ; capillary-electrophoresis ; side-chains ; recognition ; selectors ; enantiomers ; separation ; hplc ; enantioseparations
收录类别	SCI
语种	英语
WOS记录号	WOS:000315552700021
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117620]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wu, Haibo,Li, Kuiyong,Yu, Hui,et al. Investigation of peptoid chiral stationary phases varied in absolute configuration[J]. journal of chromatography a,2013,1281:155-159.
APA	Wu, Haibo,Li, Kuiyong,Yu, Hui,Ke, Yanxiong,&Liang, Xinmiao.(2013).Investigation of peptoid chiral stationary phases varied in absolute configuration.journal of chromatography a,1281,155-159.
MLA	Wu, Haibo,et al."Investigation of peptoid chiral stationary phases varied in absolute configuration".journal of chromatography a 1281(2013):155-159.